国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
2期
90-92
,共3页
社区获得性肺炎%继发性血小板增多症%可溶性P-选择素%C反应蛋白
社區穫得性肺炎%繼髮性血小闆增多癥%可溶性P-選擇素%C反應蛋白
사구획득성폐염%계발성혈소판증다증%가용성P-선택소%C반응단백
Community-acquired pneumonia%Secondary thrombocytosis%Soluble P-selectin%Creactive protein
目的 探讨成人社区获得性肺炎(CAP)患者血浆可溶性P选择素(sPs)浓度的演变趋势,结合炎症指标C反应蛋白(CRP)、血小板(PLT)的变化,了解sPs的临床作用.方法 将CAP患者分为2组:A组为36例CAP并发继发性血小板增多症(ST)患者,B组为36例无ST的CAP患者,分别检测观察对象5次的sPs浓度、CRP、PLT的数值,即入院0h、24 h、48 h、72 h和痊愈出院时；对照组为180名健康成人,分别检测sPs浓度、CRP和PLT.结果 A组sPs、CRP、PLT均较B组高(P＜0.01),三项指标间有正相关关系,sPs与CRP相关性最好(r=0.749,P＜0.01).结论 结合CRP、PLT等炎症指标,连续检测CAP患者sPs浓度对CAP病情的判断、治疗和预后可能有一定的临床价值.
目的 探討成人社區穫得性肺炎(CAP)患者血漿可溶性P選擇素(sPs)濃度的縯變趨勢,結閤炎癥指標C反應蛋白(CRP)、血小闆(PLT)的變化,瞭解sPs的臨床作用.方法 將CAP患者分為2組:A組為36例CAP併髮繼髮性血小闆增多癥(ST)患者,B組為36例無ST的CAP患者,分彆檢測觀察對象5次的sPs濃度、CRP、PLT的數值,即入院0h、24 h、48 h、72 h和痊愈齣院時；對照組為180名健康成人,分彆檢測sPs濃度、CRP和PLT.結果 A組sPs、CRP、PLT均較B組高(P＜0.01),三項指標間有正相關關繫,sPs與CRP相關性最好(r=0.749,P＜0.01).結論 結閤CRP、PLT等炎癥指標,連續檢測CAP患者sPs濃度對CAP病情的判斷、治療和預後可能有一定的臨床價值.
목적 탐토성인사구획득성폐염(CAP)환자혈장가용성P선택소(sPs)농도적연변추세,결합염증지표C반응단백(CRP)、혈소판(PLT)적변화,료해sPs적림상작용.방법 장CAP환자분위2조:A조위36례CAP병발계발성혈소판증다증(ST)환자,B조위36례무ST적CAP환자,분별검측관찰대상5차적sPs농도、CRP、PLT적수치,즉입원0h、24 h、48 h、72 h화전유출원시；대조조위180명건강성인,분별검측sPs농도、CRP화PLT.결과 A조sPs、CRP、PLT균교B조고(P＜0.01),삼항지표간유정상관관계,sPs여CRP상관성최호(r=0.749,P＜0.01).결론 결합CRP、PLT등염증지표,련속검측CAP환자sPs농도대CAP병정적판단、치료화예후가능유일정적림상개치.
Objective To understand the soluble P-selectin clinical effects,and analyse the evolution tendency of the plasma soluble P-selectin (sPs) concentration of adult community-acquired pneumonia (CAP) patients.The inflammatory biomarkers changes of C-reactive protein (CRP) and platelet (PLT) were analysed at the same time.Methods The patients were divided into two groups:group A:CAPwith secondarythrombocytosis (ST) (n =36);group B:CAP simply (n =36).The sPs concentration,the CRP and the PLT were detected when the patients were admitted,and 24 h,48 h,72 h later,and the patients recovered to discharge.In control group ( n =180),the sPs concentration,the CRP and the PLT were detected once.Results The PLT,sPs and CRP of the patients in group A were higher than those in group B (P ＜ 0.01). There were positive correlation in the three indexes,the best correlation was between sPs and CRP (r =0.749,P ＜ 0.01).Conclusions Combined with the inflammation biomarkers including CRP and PLT,continuous detecting the concentration of sPs may have some useful clinical value in the judgement,treatment and prognosis of the CAP patients.
