CAJ | 학술논문

目的观察糖耐量减低患者应用阿卡波糖干预治疗前后对血浆内皮素、C反应蛋白和纤维蛋白原的影响.方法 100例IGT患者随机分为治疗组(n=50)和对照组(n=50),两组患者均制订个性化的饮食方案及运动方案,在此基础上治疗组服用阿卡波糖.观察治疗前及治疗24周、48周后两组的ET、CRP、Fg变化及随访1年的转归情况.结果糖耐量减低患者应用阿卡波糖治疗24周、48周后,血浆内皮索、C反应蛋白、纤维蛋白原均显著下降,而对照组三者均无显著性改变;随访1年内,治疗组比对照组DM发生率明显减少,心血管事件的总发生率也明显降低,差异有统计意义.结论阿卡波糖缓解糖耐量异常患者血管炎症反应,改善血管内皮功能,改善患者的血液高凝倾向,进而减少心血管事件的发生.
목적 관찰당내량감저환자응용아잡파당간예치료전후대혈장내피소、C반응단백화섬유단백원적영향.방법 100례IGT환자수궤분위치료조(n=50)화대조조(n=50),량조환자균제정개성화적음식방안급운동방안,재차기출상치료조복용아잡파당.관찰치료전급치료24주、48주후량조적ET、CRP、Fg변화급수방1년적전귀정황.결과 당내량감저환자응용아잡파당치료24주、48주후,혈장내피색、C반응단백、섬유단백원균현저하강,이대조조삼자균무현저성개변;수방1년내,치료조비대조조DM발생솔명현감소,심혈관사건적총발생솔야명현강저,차이유통계의의.결론 아잡파당완해당내량이상환자혈관염증반응,개선혈관내피공능,개선환자적혈액고응경향,진이감소심혈관사건적발생.
Objective To observe the changes of serum endothelin, C-reactive protein and fibrinogen before and after the acarbose therapy in impaired glucose tolerance patients ( IGT ). Methods 100 IGT patients were divided randomly into 2 groups treatment group( n=50 )and control group( n=50),Two groups of patients make personalized diet and exercise scheme, Based on this, treatment group use acarbose. Observed treatment before and after 24 weeks ,48 weeks of two groups'Fg, ET, CRP changes.Results After 16, 24 weeks, the levels of ET、 CRP、 Fg decreased significantly in acarbose group, but remained unchanged in control group. 1 year follow-up, DM in the treatment group were significantly reduced than in the control group, The total incidence of cardiovascular events significantly reduced, differences are statistically significant. Conclusion Acarbose can ease patients with abnormal glucose tolerance vascular inflammatory reaction, improves endothelial function, improve blood coagulation high tendency, reducing cardioascular eents.