CAJ | 학술논문

白细胞介素-28 B(Interleukin-28B,IL-28 B)属于Ⅲ型干扰素家族,是一种新型的白细胞介素.它通过活化JAK- STAT信号通路,调节干扰素刺激基因转录,发挥抗病毒等生物学效应.新近研究发现,IL-28B基因多态性与丙型病毒性肝炎的发病、抗病毒治疗应答和疾病转归等密切相关.因此,通过对二者相关性的研究,可能有助于临床医师更合理的选择丙型肝炎的治疗措施、开展个性化治疗、及早判断患者的预后.
백세포개소-28 B(Interleukin-28B,IL-28 B)속우Ⅲ형간우소가족,시일충신형적백세포개소.타통과활화JAK- STAT신호통로,조절간우소자격기인전록,발휘항병독등생물학효응.신근연구발현,IL-28B기인다태성여병형병독성간염적발병、항병독치료응답화질병전귀등밀절상관.인차,통과대이자상관성적연구,가능유조우림상의사경합리적선택병형간염적치료조시、개전개성화치료、급조판단환자적예후.
As a new interleukin,the interleukin-28 B belongs to the type Ⅲ interferon family.It regulates the transcription of IFN stimulated gene and exerts antiviral biological effect by activating JAKSTAT signal pathway.Recent studies identify that IL-28B gene polymorphism is strongly associated with the pathogenesis of hepatitis C virus infection,its response to antiviral treatment as well as its prognosis.Therefore,the study on their association may be helpful for physicians to provide more choices of therapeutic measures,to carry out more personalized therapy,and foresee the patients ' prognosis early.