中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2010年
12期
922-924
,共3页
张萍%梁慧%吴世凤%陈奇盛%蓝海云%陈蝉
張萍%樑慧%吳世鳳%陳奇盛%藍海雲%陳蟬
장평%량혜%오세봉%진기성%람해운%진선
糖尿病,2型%持续皮下输注胰岛素%动态血糖监测系统%每天多次胰岛素皮下注射
糖尿病,2型%持續皮下輸註胰島素%動態血糖鑑測繫統%每天多次胰島素皮下註射
당뇨병,2형%지속피하수주이도소%동태혈당감측계통%매천다차이도소피하주사
Diabetes mellitus，type 2%Continuous subcutaneous insulin infusion% Continuous glucose minitoring system% Multiple subcutaneous insulin injections
目的 探讨持续皮下输注胰岛素(CSII)联合动态血糖监测系统(CGMS)治疗T2DM的疗效.方法 78例T2DM患者随机分为3组,CSII+CGMS组、CSII组和MSII组,各26例,比较治疗3 d的日内平均血糖(MBG)、平均血糖漂移幅度(MAGE)、血糖达标所需时间、胰岛素用量、低血糖情况.结果 3组治疗3d后的MBG以CSII+CGMS组、CSII组较MSII组下降更明显(P＜0.01).CSII+CGMS组的MAGE显著低于CSII组和MSII组(P＜0.01).血糖达标所需时间MSII组＞CSII组＞CSII+CGMS组(P＜0.01),所需胰岛素用量MSII组＞CSII+CGMS组(P＜0.01),MSII组＞CSII组(P＜0.05),CSII+CGMS组在动态血糖监测时间段低血糖事件发生44次,无症状性低血糖39次,CSII组低血糖事件发生10次,MSII组低血糖事件发生14次.结论 CSII+CGMS治疗2型糖尿病更加安全有效.
目的 探討持續皮下輸註胰島素(CSII)聯閤動態血糖鑑測繫統(CGMS)治療T2DM的療效.方法 78例T2DM患者隨機分為3組,CSII+CGMS組、CSII組和MSII組,各26例,比較治療3 d的日內平均血糖(MBG)、平均血糖漂移幅度(MAGE)、血糖達標所需時間、胰島素用量、低血糖情況.結果 3組治療3d後的MBG以CSII+CGMS組、CSII組較MSII組下降更明顯(P＜0.01).CSII+CGMS組的MAGE顯著低于CSII組和MSII組(P＜0.01).血糖達標所需時間MSII組＞CSII組＞CSII+CGMS組(P＜0.01),所需胰島素用量MSII組＞CSII+CGMS組(P＜0.01),MSII組＞CSII組(P＜0.05),CSII+CGMS組在動態血糖鑑測時間段低血糖事件髮生44次,無癥狀性低血糖39次,CSII組低血糖事件髮生10次,MSII組低血糖事件髮生14次.結論 CSII+CGMS治療2型糖尿病更加安全有效.
목적 탐토지속피하수주이도소(CSII)연합동태혈당감측계통(CGMS)치료T2DM적료효.방법 78례T2DM환자수궤분위3조,CSII+CGMS조、CSII조화MSII조,각26례,비교치료3 d적일내평균혈당(MBG)、평균혈당표이폭도(MAGE)、혈당체표소수시간、이도소용량、저혈당정황.결과 3조치료3d후적MBG이CSII+CGMS조、CSII조교MSII조하강경명현(P＜0.01).CSII+CGMS조적MAGE현저저우CSII조화MSII조(P＜0.01).혈당체표소수시간MSII조＞CSII조＞CSII+CGMS조(P＜0.01),소수이도소용량MSII조＞CSII+CGMS조(P＜0.01),MSII조＞CSII조(P＜0.05),CSII+CGMS조재동태혈당감측시간단저혈당사건발생44차,무증상성저혈당39차,CSII조저혈당사건발생10차,MSII조저혈당사건발생14차.결론 CSII+CGMS치료2형당뇨병경가안전유효.
Objective To observe the clinical effects and safety of continuous subcutaneous insulin infusion(CSII) combined with continuous glucose monitoring system(CGMS) in type 2 diabetes mellitus（T2DM）. Methods 78 cases were randomly divided into three groups: CSII plus CGMS group, CSII group, multiple subcutaneous insulin injection (MSII).The mean blood glucose (MBG) and mean amplitude of glycemic excursions (MAGE) after treatment for three days,glucose target time, dosage of insulin and frequency of hypoglycemic incidence rates were compared among three groups. Results The MBG was significantly decreased（P<0.05）in all groups,and the fall degree in group of CSII plus CGMS and group of CSII was larger than in group of MSII（P<0.01）.MAGE was lower in group of CSII plus CGMS than in CSII and MSII groups (P＜0.01). The glucose target time was shorter in CSII plus CGMS than in CSII and MSII group (P＜0.01).The insulin dose was larger in MSII than in CSII plus CGMS and in CSII group (P＜0.01 or 0.05). Numbers of hypoglycemic events were 44 in group of CSII plus CGMS (on the addition of 39 asymptomatic hypoglycemia), 14 in MSII, and 10 in CSII group. Conclusion CSII therapy in combination with CGMS is safer and more effective in treatment of T2DM.
