血小板膜糖蛋白αⅡbA477P(A446P)突变对αⅡbβ3复合物表达的影响
혈소판막당단백αⅡbA477P(A446P)돌변대αⅡbβ3복합물표체적영향
Effect of αⅡb Ala477Pro(A446P) mutation of the platelet glycoprotein on the expression of αⅡbβ3 complex
  • 万方数据
    中南大学学报（医学版） 중남대학학보（의학판）
    JOURNAL OF CENTRAL SOUTH UNIVERSITY (MEDICAL SCIENCES)
    2009年 8期 712-717 ,共6页

    袁小瑜%陈方平%夏昆%付敢%蹇在伏%解勤之%王光平

    원소유%진방평%하곤%부감%건재복%해근지%왕광평

    血小板无力症%整联蛋白αⅡbβ3%β-螺旋%突变%表达 血小闆無力癥%整聯蛋白αⅡbβ3%β-螺鏇%突變%錶達
    혈소판무력증%정련단백αⅡbβ3%β-라선%돌변%표체
    Glanzmann thrombasthenia%integrin αⅡbβ3%β-propeller%mutation%expression
    β3复合物的12.95%.结论:αⅡbA477P(A446P)显著降低了αⅡbβ3复合物在细胞膜表面的表达,其机制可能是该位点的突变干扰了αⅡb和β3正常结合或者影响了αⅡb蛋白的正常构型.
    β3복합물적12.95%.결론:αⅡbA477P(A446P)현저강저료αⅡbβ3복합물재세포막표면적표체,기궤제가능시해위점적돌변간우료αⅡb화β3정상결합혹자영향료αⅡb단백적정상구형.
    ly reduces the expression of αⅡbβ3 complex on the membrane. This mutation may interfere the formation of αⅡbβ3 complex or impair the proper conformation of αⅡb subunit.
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