CAJ | 학술논문

研究了解新疆维吾尔族冠心病患者血管紧张素转换酶(ACE)基因、内皮型-氧化氨合酶(eNOS)基因、凝血因子VII(FVII)基因、细胞黏附分子-1(ICAM-1)基因等的多态性变化.入选已确诊的维吾尔族冠心病患者124例和维吾尔族健康志愿者50例.采用聚合酶链式反应-限制性片段多态性(PCR-RFLP)方法,分别检测及比较维吾尔族冠心病患者及健康志愿者4种基因型及其等位基因频率.结果显示,冠心病组与健康对照组相比,ACE基因、FVII基因、ICAM-1基因在基因型及等位基因频率方面均无显著性差异(P>0.05);冠心病组在eNOS基因型和等位基因频率分布两方面与健康对照组比较,均有显著性差异(P<O.05).结论为ACE;基因、FVII基因、ICAM-1基因多态性与新疆维吾尔族冠心病患者的关系不明显,而eNOS基因多态性与维吾尔族冠心病患者有相关性.
연구료해신강유오이족관심병환자혈관긴장소전환매(ACE)기인、내피형-양화안합매(eNOS)기인、응혈인자VII(FVII)기인、세포점부분자-1(ICAM-1)기인등적다태성변화.입선이학진적유오이족관심병환자124례화유오이족건강지원자50례.채용취합매련식반응-한제성편단다태성(PCR-RFLP)방법,분별검측급비교유오이족관심병환자급건강지원자4충기인형급기등위기인빈솔.결과현시,관심병조여건강대조조상비,ACE기인、FVII기인、ICAM-1기인재기인형급등위기인빈솔방면균무현저성차이(P>0.05);관심병조재eNOS기인형화등위기인빈솔분포량방면여건강대조조비교,균유현저성차이(P<O.05).결론위ACE;기인、FVII기인、ICAM-1기인다태성여신강유오이족관심병환자적관계불명현,이eNOS기인다태성여유오이족관심병환자유상관성.
Hie gene polymorphism of Angiotensin -Converting Enzyme (ACE) gene, Nitric Oxide Synthase (eNOS) gene, coagulation Factor VII (FVII) gene and Intercellular Cell Adhesion Molecules-1 (ICAM-1) in Uighur patients with Coronary Heart Disease (CHD) in Xinjiang are studied in this paper. The four types of genes related to CHD are compared to each other by using polymerized chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 124 cases of CHD Uighur patients and SO healthy subjects as verified by diagnosis. The results show that there are no significant differences in genotype distribution and allele frequencies of ACE gene, FCII gene, ICAM-1 gene in Uighur patients with CHD when compared to healthy subjects (P>0.05). There are significant differences in genotype distribution and allele frequencies of eNOS gene in Uighur patients with CHD when compared to healthy subjects (P<0.05). There is no correlation in genotype distribution and allele frequencies at ACE gene, FVII gene, ICAM-l gene in Uighur patients with CHD in Xinjiang. Significant correlation is discovered in genotype distribution and allele frequencies of eNOS gene in Uighur patients with CHD in Xinjiang.