国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2012年
4期
165-167
,共3页
孙景異%王晨%高秀媛%崔海洋%任国良%李继珊
孫景異%王晨%高秀媛%崔海洋%任國良%李繼珊
손경이%왕신%고수원%최해양%임국량%리계산
手足口病%肠道病毒%Real time-PCR%病毒分离
手足口病%腸道病毒%Real time-PCR%病毒分離
수족구병%장도병독%Real time-PCR%병독분리
hand-foot-mouth disease%enterovirus%real-time RT-PCR%virus isolation
目的 对2010-2011年北京市西城区(南区)手足口病患者进行肠道病毒病原体检测,分析肠道病毒病原学特征,为手足口病防控提供科学依据.方法 采集医疗机构临床诊断为手足口病患者咽拭子和粪便标本共418份,应用Real time-PCR检测咽拭子标本病毒核酸;并对粪便标本进行病毒分离.结果 418份标本中,肠道病毒总体检出率为53.59%(224/418).2010年咽拭子标本未分型肠道病毒阳性检出率(36.26%)高于2011年(16.89%),结果差别有统计学意义(x2=13.80,P <0.005);2011年咽拭子标本CoxA16型病毒阳性检出率(26.03%)高于2010年(10.99%),差别有统计学意义(x2=8.58,P<0.005).分别比较两年采集的咽拭子标本,发病3天内和3天以上采集的标本检出率差异均有统计学意义(2010年:x2 =5.85,P<0.05;2011年:x2=15.26,P<0.005).结论 引起北京市西城区(南区)手足口病流行的主要肠道病原体,2010年为未分型肠道病毒,2011年为CoxA16.在发病3天内采集患者咽拭子标本,有助于提高病毒检出率.
目的 對2010-2011年北京市西城區(南區)手足口病患者進行腸道病毒病原體檢測,分析腸道病毒病原學特徵,為手足口病防控提供科學依據.方法 採集醫療機構臨床診斷為手足口病患者嚥拭子和糞便標本共418份,應用Real time-PCR檢測嚥拭子標本病毒覈痠;併對糞便標本進行病毒分離.結果 418份標本中,腸道病毒總體檢齣率為53.59%(224/418).2010年嚥拭子標本未分型腸道病毒暘性檢齣率(36.26%)高于2011年(16.89%),結果差彆有統計學意義(x2=13.80,P <0.005);2011年嚥拭子標本CoxA16型病毒暘性檢齣率(26.03%)高于2010年(10.99%),差彆有統計學意義(x2=8.58,P<0.005).分彆比較兩年採集的嚥拭子標本,髮病3天內和3天以上採集的標本檢齣率差異均有統計學意義(2010年:x2 =5.85,P<0.05;2011年:x2=15.26,P<0.005).結論 引起北京市西城區(南區)手足口病流行的主要腸道病原體,2010年為未分型腸道病毒,2011年為CoxA16.在髮病3天內採集患者嚥拭子標本,有助于提高病毒檢齣率.
목적 대2010-2011년북경시서성구(남구)수족구병환자진행장도병독병원체검측,분석장도병독병원학특정,위수족구병방공제공과학의거.방법 채집의료궤구림상진단위수족구병환자인식자화분편표본공418빈,응용Real time-PCR검측인식자표본병독핵산;병대분편표본진행병독분리.결과 418빈표본중,장도병독총체검출솔위53.59%(224/418).2010년인식자표본미분형장도병독양성검출솔(36.26%)고우2011년(16.89%),결과차별유통계학의의(x2=13.80,P <0.005);2011년인식자표본CoxA16형병독양성검출솔(26.03%)고우2010년(10.99%),차별유통계학의의(x2=8.58,P<0.005).분별비교량년채집적인식자표본,발병3천내화3천이상채집적표본검출솔차이균유통계학의의(2010년:x2 =5.85,P<0.05;2011년:x2=15.26,P<0.005).결론 인기북경시서성구(남구)수족구병류행적주요장도병원체,2010년위미분형장도병독,2011년위CoxA16.재발병3천내채집환자인식자표본,유조우제고병독검출솔.
Objective To find the aetiology characteristics from Hand-foot-mouth Disease (HFMD) cases in Xicheng South District of Beijing from 2010 to 2011,and analyse the distribution of enterovirus serotypes,provide a scientific basis for HFMD prevention and control work.Methods The medical institutions and clinical diagnosis of cases information were collected.Throat swabs and faecal samples of 418 cases were also cellected.Rea- time RT-PCR technology was used to detect viral nucleic acid.We isolated virus from faecal samples.Results The enterovirus detection positive rate was 53.59% (224/418).Comparing 2010 with 2011,non-typeable enterovirus detection rate in throat swab specimens was higher in 2010 ( x2 =13.80,P < 0.005 ),CoxA 16 was higher in 2011 ( x2 =8.58,P < 0.005 ).There were significant difference (2010:x2 =5.85,P < 0.05 ;2011:x2 =15.26,P < 0.005 ) in detection positive rate between specimens collected within 3 days and more than 3 days.Conclusion The main reason of epidemic enterovirus for HFMD was non-typeable enterovirus in 2010,Coxsackie A16 type in 2011.To collect throat swab samples within 3 days will improve virus detection rate.