白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2010年
11期
702-704
,共3页
淋巴瘤,大细胞,弥漫型%NF-κB%治疗%脱冬肽酶募集结构域
淋巴瘤,大細胞,瀰漫型%NF-κB%治療%脫鼕肽酶募集結構域
림파류,대세포,미만형%NF-κB%치료%탈동태매모집결구역
Lymphoma,large-cell,diffuse%NF-kappa B%Therapy%CARD11
弥漫性大B细胞淋巴瘤(DLBCL)是恶性淋巴瘤中最常见的类型,其形态学、免疫表型、遗传学特点及临床预后各异.目前国内外绝大多数学者认为,NF-κB持续活化是活化B细胞DLBCL(ABC-DLBCL)预后不良的原因之一,而胱冬肽酶募集结构域(CARD11)是NF-κB信号通路中的重要蛋白分子,丰富的临床前资料也证明了CARD11在DLBCL中的重要性.对CARD11与NF-κB及DLBCL的相关性进行概括,以更清楚地了解DLBCL的发病机制和治疗靶向.
瀰漫性大B細胞淋巴瘤(DLBCL)是噁性淋巴瘤中最常見的類型,其形態學、免疫錶型、遺傳學特點及臨床預後各異.目前國內外絕大多數學者認為,NF-κB持續活化是活化B細胞DLBCL(ABC-DLBCL)預後不良的原因之一,而胱鼕肽酶募集結構域(CARD11)是NF-κB信號通路中的重要蛋白分子,豐富的臨床前資料也證明瞭CARD11在DLBCL中的重要性.對CARD11與NF-κB及DLBCL的相關性進行概括,以更清楚地瞭解DLBCL的髮病機製和治療靶嚮.
미만성대B세포림파류(DLBCL)시악성림파류중최상견적류형,기형태학、면역표형、유전학특점급림상예후각이.목전국내외절대다수학자인위,NF-κB지속활화시활화B세포DLBCL(ABC-DLBCL)예후불량적원인지일,이광동태매모집결구역(CARD11)시NF-κB신호통로중적중요단백분자,봉부적림상전자료야증명료CARD11재DLBCL중적중요성.대CARD11여NF-κB급DLBCL적상관성진행개괄,이경청초지료해DLBCL적발병궤제화치료파향.
Diffuse large B-cell lymphoma (DLBCL) represents the most common type of malignant lymphoma. DLBCL is heterogeneous with respect to morphology, immunophenotype, biology, clinical presentation and outcome. Constitutive activity of the NF-κB pathway may contribute to the poor prognosis of patients with activated B cell-like (ABC) subgroup of DLBCL, caspase recruitment domain 11 (CARD11) is the important signal protein in the signaling pathway of NF-κB. Furthermore, various pre-clinical data have proved the importance of CARD11 in DLBCL. This review summarizes the biological characteristics of CARD11, and its relationship with NF-κB signaling transduction pathway and the outcome of DLBCL, so that we can better understanding the pathogenesis and new therapeutic target of DLBCL.
