国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
13期
988-991
,共4页
李琪%平芬%韩书芝%张凤蕊%李萍
李琪%平芬%韓書芝%張鳳蕊%李萍
리기%평분%한서지%장봉예%리평
阻塞性睡眠呼吸暂停低通气综合征%高血压%氧化低密度脂蛋白%总抗氧化能力
阻塞性睡眠呼吸暫停低通氣綜閤徵%高血壓%氧化低密度脂蛋白%總抗氧化能力
조새성수면호흡잠정저통기종합정%고혈압%양화저밀도지단백%총항양화능력
Obstructive sleep apnea-hypopnea syndrome%Hypertension%Oxidized low density lipoprotein%Total-antoxidant capability
目的 探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)及OSAHS合并高血压患者血清氧化低密度脂蛋白(oxidized low density lipoprotein,OX-LDL)、总抗氧化能力(total-antoxidant capability,T-AOC)水平的变化.方法 选择OSAHS患者22例,OSAHS合并高血压患者24例；健康对照组24例,测定血清OX-LDL、T-AOC水平.并与睡眠呼吸监测指标进行相关分析.结果 与正常对照组比较,OSAHS组及OSAHS合并高血压组血清T-AOC活性均降低(P＜0.05),OX-LDL浓度均升高(P＜0.01).OSAHS及OSAHS合并高血压患者血清OX-LDL、T-AOC水平与反映睡眠呼吸暂停严重程度的指标有相关性(P＜0.01).结论 OSAHS患者存在OX-LDL、T-AOC水平的变化,且与其病情严重程度相关；氧化应激及氧化损伤在OSAHS合并高血压患者中更明显.
目的 探討阻塞性睡眠呼吸暫停低通氣綜閤徵(obstructive sleep apnea-hypopnea syndrome,OSAHS)及OSAHS閤併高血壓患者血清氧化低密度脂蛋白(oxidized low density lipoprotein,OX-LDL)、總抗氧化能力(total-antoxidant capability,T-AOC)水平的變化.方法 選擇OSAHS患者22例,OSAHS閤併高血壓患者24例；健康對照組24例,測定血清OX-LDL、T-AOC水平.併與睡眠呼吸鑑測指標進行相關分析.結果 與正常對照組比較,OSAHS組及OSAHS閤併高血壓組血清T-AOC活性均降低(P＜0.05),OX-LDL濃度均升高(P＜0.01).OSAHS及OSAHS閤併高血壓患者血清OX-LDL、T-AOC水平與反映睡眠呼吸暫停嚴重程度的指標有相關性(P＜0.01).結論 OSAHS患者存在OX-LDL、T-AOC水平的變化,且與其病情嚴重程度相關；氧化應激及氧化損傷在OSAHS閤併高血壓患者中更明顯.
목적 탐토조새성수면호흡잠정저통기종합정(obstructive sleep apnea-hypopnea syndrome,OSAHS)급OSAHS합병고혈압환자혈청양화저밀도지단백(oxidized low density lipoprotein,OX-LDL)、총항양화능력(total-antoxidant capability,T-AOC)수평적변화.방법 선택OSAHS환자22례,OSAHS합병고혈압환자24례；건강대조조24례,측정혈청OX-LDL、T-AOC수평.병여수면호흡감측지표진행상관분석.결과 여정상대조조비교,OSAHS조급OSAHS합병고혈압조혈청T-AOC활성균강저(P＜0.05),OX-LDL농도균승고(P＜0.01).OSAHS급OSAHS합병고혈압환자혈청OX-LDL、T-AOC수평여반영수면호흡잠정엄중정도적지표유상관성(P＜0.01).결론 OSAHS환자존재OX-LDL、T-AOC수평적변화,차여기병정엄중정도상관；양화응격급양화손상재OSAHS합병고혈압환자중경명현.
Objective To study the changes of serum oxidized low density lipoprotein (OX-LDL)and total-antoxidant capability (T-AOC) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and obsturctive sleep apnea-hypopnea associated hypertension (OSAHAHT).Methods 22 patients with OSAHS and 24 patients with OSAHAHT were included in this study,24 healthy subjects were introduced as control group. The levels of serum OX-LDL and T-AOC were measured.The correlation analysis were made among the serum levels of OX-LDL,T-AOC and the indices of polysomnography.Results The activities of T-AOC are lower in patients with OSAHS and OSAHAHT than those in control group ( P ＜0.05) and the concentration of OX-LDL is higher in patients with OSAHS and OSAHAHT than that in control group ( P ＜0,01).The serum levels of OX-LDL,T-AOC in patients with OSAHS and OSAHAHT are correlated significantly with the indices of polysomnography which reflect the severity of obstructive sleep apnea ( P ＜0.01 ).Conclusions There serum levels of OX-LDL,T-AOC might be changed in patients with OSAHS,and the changes are related to the servity of the disease.The oxidative stress process is more severe in patients with OSAHAHT than in OSAHS.
