中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2010年
10期
666-670
,共5页
朱欣%应莉莎%许沈华%朱赤红%谢锦波
硃訢%應莉莎%許瀋華%硃赤紅%謝錦波
주흔%응리사%허침화%주적홍%사금파
卵巢肿瘤%白细胞介素10%白细胞介素2%预后
卵巢腫瘤%白細胞介素10%白細胞介素2%預後
란소종류%백세포개소10%백세포개소2%예후
Ovarian neoplasms%Interleukin-10%Interleukin-2%Prognosis
目的 探讨晚期卵巢浆液性腺癌患者术前血清中6种细胞因子水平与临床病理因素及预后的关系.方法 用流式细胞微球阵列术检测51例晚期卵巢癌患者及46例健康女性(对照组)血清中干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-2、IL-4、IL-5、IL-10的表达水平.结果 卵巢癌患者IFN-γ(20.68±11.45)、IL-2(4.54±1.18)、IL-4(5.66±2.25)、IL-5(2.72±0.86)μg/L及IL-10(5.93±7.92)μg/L高于对照组,差异有统计学意义(P＜0.01或P＜0.05);而TNF-α(7.53±8.47)低于对照组,差异有统计学意义(P＜0.01);卵巢癌患者的IFN-γ/IL-4比值(3.93±2.34)低于对照组,差异有统计学意义(P＜0.01).Kaplan-Meier生存分析结果表明年龄(P=0.016)、绝经状态(P=0.001)、IL-10水平(P=0.010)与患者生存状态明显相关;Cox回归分析显示,IL-2(P=0.045)和IL-10(P=0.007)是影响预后的独立因素,不受其他细胞因子以及临床参数诸如临床分期、分化程度、年龄、是否淋巴结转移、体质量指数、是否绝经、发病部位等的影响.结论 晚期卵巢癌患者机体出现辅助性T细胞(Th)1/Th2失衡和不同程度的免疫机制紊乱.年龄和绝经状态是影响患者生存的重要因素,IL-2和IL-10水平是卵巢癌的独立预后因素.
目的 探討晚期卵巢漿液性腺癌患者術前血清中6種細胞因子水平與臨床病理因素及預後的關繫.方法 用流式細胞微毬陣列術檢測51例晚期卵巢癌患者及46例健康女性(對照組)血清中榦擾素-γ(IFN-γ)、腫瘤壞死因子-α(TNF-α)、白細胞介素(IL)-2、IL-4、IL-5、IL-10的錶達水平.結果 卵巢癌患者IFN-γ(20.68±11.45)、IL-2(4.54±1.18)、IL-4(5.66±2.25)、IL-5(2.72±0.86)μg/L及IL-10(5.93±7.92)μg/L高于對照組,差異有統計學意義(P＜0.01或P＜0.05);而TNF-α(7.53±8.47)低于對照組,差異有統計學意義(P＜0.01);卵巢癌患者的IFN-γ/IL-4比值(3.93±2.34)低于對照組,差異有統計學意義(P＜0.01).Kaplan-Meier生存分析結果錶明年齡(P=0.016)、絕經狀態(P=0.001)、IL-10水平(P=0.010)與患者生存狀態明顯相關;Cox迴歸分析顯示,IL-2(P=0.045)和IL-10(P=0.007)是影響預後的獨立因素,不受其他細胞因子以及臨床參數諸如臨床分期、分化程度、年齡、是否淋巴結轉移、體質量指數、是否絕經、髮病部位等的影響.結論 晚期卵巢癌患者機體齣現輔助性T細胞(Th)1/Th2失衡和不同程度的免疫機製紊亂.年齡和絕經狀態是影響患者生存的重要因素,IL-2和IL-10水平是卵巢癌的獨立預後因素.
목적 탐토만기란소장액성선암환자술전혈청중6충세포인자수평여림상병리인소급예후적관계.방법 용류식세포미구진렬술검측51례만기란소암환자급46례건강녀성(대조조)혈청중간우소-γ(IFN-γ)、종류배사인자-α(TNF-α)、백세포개소(IL)-2、IL-4、IL-5、IL-10적표체수평.결과 란소암환자IFN-γ(20.68±11.45)、IL-2(4.54±1.18)、IL-4(5.66±2.25)、IL-5(2.72±0.86)μg/L급IL-10(5.93±7.92)μg/L고우대조조,차이유통계학의의(P＜0.01혹P＜0.05);이TNF-α(7.53±8.47)저우대조조,차이유통계학의의(P＜0.01);란소암환자적IFN-γ/IL-4비치(3.93±2.34)저우대조조,차이유통계학의의(P＜0.01).Kaplan-Meier생존분석결과표명년령(P=0.016)、절경상태(P=0.001)、IL-10수평(P=0.010)여환자생존상태명현상관;Cox회귀분석현시,IL-2(P=0.045)화IL-10(P=0.007)시영향예후적독립인소,불수기타세포인자이급림상삼수제여림상분기、분화정도、년령、시부림파결전이、체질량지수、시부절경、발병부위등적영향.결론 만기란소암환자궤체출현보조성T세포(Th)1/Th2실형화불동정도적면역궤제문란.년령화절경상태시영향환자생존적중요인소,IL-2화IL-10수평시란소암적독립예후인소.
Objective To study the clinicopathologic and prognostic significance of serum levels of six cytokines (IFN-γ, TNF-α, IL-10, IL-5, IL-4, IL-2) in patients with advanced serous ovarian cancer prior to surgery. Methods The serum levels of six cytokines were detected in 51 patients with advanced serous ovarian cancer and 46 healthy controls, using cytometric bead arrays. Results The serum levels of IFN-γ (20.68 ± 11.45), IL-2 (4.54 ± 1.18), IL-4 (5.66 ±2.25), IL-5 (2.72 ±0.86) μg/L and IL-10 (5.93 ±7.92) μg/L were higher (P＜0.01, P＜0.05) and the serum level of TNF-α(7.53 ±8.47) was lower (P ＜ 0.01 ) in patients with advanced serous ovarian cancer than those in the healthy controls. The IFN-γ/IL-4 ratio (3.93 ±2.34) of the patients was lower than that of the controls ( P ＜ 0.01 ). KaplanMeier analysis revealed that patient's age (P =0.016), menopausal status (P = 0.001 ) and serum IL-10 level (P = 0.010) correlated significantly with patient's survival. Cox regression analysis showed that serum IL-2 ( P = 0.045 ) and IL-10 levels ( P = 0.007 ) were the independent prognostic factors. Conclusions Patients with advanced serous ovarian cancer have Th1/Th2 imbalance and immune function disturbance.The age of patients and menopausal status are important prognostic factors. IL-2 and IL-10 level are also independent predictors of survival.
