体内高糖环境下肝脏卵圆细胞的功能研究
체내고당배경하간장란원세포적공능연구
The function of hepatic oval cells under high glucose condition in vivo
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2011年 7期 604-606 ,共3页

    李影%赵丽娟%李艳香%夏芳珍%陆颖理

    리영%조려연%리염향%하방진%륙영리

    高血糖%肝脏卵圆细胞%胰岛素分泌细胞%体内 高血糖%肝髒卵圓細胞%胰島素分泌細胞%體內
    고혈당%간장란원세포%이도소분비세포%체내
    High glucose%Hepatic oval cell%Insulin-producing cell%in vivo
    以链脲佐菌素(STZ)诱导肝脏卵圆细胞模型大鼠体内高血糖,检测肝脏中胰岛素和转录因子(PDX-1、Nkx6.1)mRNA的表达.可见体内高糖环境下,肝脏胰岛素染色阳性,Nkx6.1和Pdx1mRNA表达明显增强,并有胰岛素1 mRNA的表达.提示高糖环境下,肝脏卵圆细胞可分化为胰岛素分泌细胞.
    이련뇨좌균소(STZ)유도간장란원세포모형대서체내고혈당,검측간장중이도소화전록인자(PDX-1、Nkx6.1)mRNA적표체.가견체내고당배경하,간장이도소염색양성,Nkx6.1화Pdx1mRNA표체명현증강,병유이도소1 mRNA적표체.제시고당배경하,간장란원세포가분화위이도소분비세포.
    Rat hepatic oval cell model was induced by hyperglycemia and streptozotocin in vivo. Expression of insulin and mRNA expression of pancreatic transcription factors(Nkx6.1, PDX-1) were carried out. It showed that under high glucose, liver tissues were positive for insulin staining, the expression of Nkx6.1 and Pdx-1mRNA was significantly enhanced, and insulin-1mRNA was found to be expressed. The result suggests that under high glucose, hepatic oval cells can differentiate into insulin-producing cells.
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