CAJ | 학술논문

目的评价三维打印技术制备的多药控释型载药人工骨的生物相容性.方法利用三维打印技术制备多药控释型载药人工骨,并进行急性毒性试验、热源试验、皮肤刺激试验、溶血试验、微核试验和肌肉埋植试验等检测评价其生物相容性.结果该多药控释型载药人工骨无全身急性毒性反应、无热源效应;皮肤刺激实验局部皮肤未见红斑、水肿反应;溶血率为0.29%,有良好的血液相容性;微核实验未见致突变现象.无细胞遗传毒性作用;肌肉埋植实验未见局部组织变性、坏死或排斥现象.结论三维打印技术制备的多药控释型载药人工骨具有良好的生物相容性,符合医用生物材料的性能要求.
목적 평개삼유타인기술제비적다약공석형재약인공골적생물상용성.방법 이용삼유타인기술제비다약공석형재약인공골,병진행급성독성시험、열원시험、피부자격시험、용혈시험、미핵시험화기육매식시험등검측평개기생물상용성.결과 해다약공석형재약인공골무전신급성독성반응、무열원효응;피부자격실험국부피부미견홍반、수종반응;용혈솔위0.29%,유량호적혈액상용성;미핵실험미견치돌변현상.무세포유전독성작용;기육매식실험미견국부조직변성、배사혹배척현상.결론 삼유타인기술제비적다약공석형재약인공골구유량호적생물상용성,부합의용생물재료적성능요구.
Objective To evaluate the biocompatibility of porous drug implant scaffolds prepared by 3D printing technique. Methods Porous drug implant scaffolds were fabricated by 3D printing technique, and a series of tests were carried out to validate the biocompatibility, including acute systemic toxicity, hot source test, local irritation reaction, micronucleus test, muscle implant test and so on. Results The porous drug implant scaffolds showed no acute systemic toxicity, no pyrogenetic effect, no local erythema and edema in local irritation re-action, hemolysis rate of 0.29%, no cellular genetoxic. No local tissue denaturation, necrosis and exclusion were found in intramuscular implant test. Conclusion With good biocompatibility, the porous drug implant scaffold fabricated by 3D printing technique can meet the clinical requirement for biomaterial.