国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2011年
6期
325-330
,共6页
程蕾蕾%陈章炜%舒先红%马剑英%钱菊英%常书福%陈永乐%姚瑞明%葛均波
程蕾蕾%陳章煒%舒先紅%馬劍英%錢菊英%常書福%陳永樂%姚瑞明%葛均波
정뢰뢰%진장위%서선홍%마검영%전국영%상서복%진영악%요서명%갈균파
心脏再同步化治疗%二维斑点追踪显像%环向应变%径向收缩速度%径向应变
心髒再同步化治療%二維斑點追蹤顯像%環嚮應變%徑嚮收縮速度%徑嚮應變
심장재동보화치료%이유반점추종현상%배향응변%경향수축속도%경향응변
Cardiac resynchronization therapy%Two-dimentional speckle tracking imaging%Circumferential strain%Radial velocity%Radial strain
目的 评价潘生丁负荷实时心肌声学造影分析猪心肌不同程度微梗死后收缩同步性的价值.方法 小型猪18只,随机分为3组,经心导管在冠状动脉前降支注入微栓塞球(A组:微球剂量5万,3头；B组:微球剂量12万,8头；C组:微球剂量15万,7头).分别在基础状态和微栓塞后6h、1周行潘生丁负荷实时心肌声学造影(RT-MCE)检查.应用Philips Q-Lab 8.1工作站分析栓塞相关节段即左室前壁和前间隔基底段和中间段二维斑点追踪显像(STI)的环向应变、径向收缩速度和径向应变的峰值以及达峰时间.结果 在静息状态下,没有检测到微栓塞对心脏收缩同步性的影响(P＞0.05)；潘生丁负荷试验显示:微栓塞1周后,相关心肌节段的环向应变达峰时间延长(组间比较和组内比较,P＜0.05)；而径向应变达峰时间从微栓塞后6h就表现为延长,并延续到1周后(P＜0.05).结论 潘生丁负荷RT-MCE能准确分析心肌血流灌注,微栓塞相关心肌节段环向应变和径向应变达峰时间延长.
目的 評價潘生丁負荷實時心肌聲學造影分析豬心肌不同程度微梗死後收縮同步性的價值.方法 小型豬18隻,隨機分為3組,經心導管在冠狀動脈前降支註入微栓塞毬(A組:微毬劑量5萬,3頭；B組:微毬劑量12萬,8頭；C組:微毬劑量15萬,7頭).分彆在基礎狀態和微栓塞後6h、1週行潘生丁負荷實時心肌聲學造影(RT-MCE)檢查.應用Philips Q-Lab 8.1工作站分析栓塞相關節段即左室前壁和前間隔基底段和中間段二維斑點追蹤顯像(STI)的環嚮應變、徑嚮收縮速度和徑嚮應變的峰值以及達峰時間.結果 在靜息狀態下,沒有檢測到微栓塞對心髒收縮同步性的影響(P＞0.05)；潘生丁負荷試驗顯示:微栓塞1週後,相關心肌節段的環嚮應變達峰時間延長(組間比較和組內比較,P＜0.05)；而徑嚮應變達峰時間從微栓塞後6h就錶現為延長,併延續到1週後(P＜0.05).結論 潘生丁負荷RT-MCE能準確分析心肌血流灌註,微栓塞相關心肌節段環嚮應變和徑嚮應變達峰時間延長.
목적 평개반생정부하실시심기성학조영분석저심기불동정도미경사후수축동보성적개치.방법 소형저18지,수궤분위3조,경심도관재관상동맥전강지주입미전새구(A조:미구제량5만,3두；B조:미구제량12만,8두；C조:미구제량15만,7두).분별재기출상태화미전새후6h、1주행반생정부하실시심기성학조영(RT-MCE)검사.응용Philips Q-Lab 8.1공작참분석전새상관절단즉좌실전벽화전간격기저단화중간단이유반점추종현상(STI)적배향응변、경향수축속도화경향응변적봉치이급체봉시간.결과 재정식상태하,몰유검측도미전새대심장수축동보성적영향(P＞0.05)；반생정부하시험현시:미전새1주후,상관심기절단적배향응변체봉시간연장(조간비교화조내비교,P＜0.05)；이경향응변체봉시간종미전새후6h취표현위연장,병연속도1주후(P＜0.05).결론 반생정부하RT-MCE능준학분석심기혈류관주,미전새상관심기절단배향응변화경향응변체봉시간연장.
Objective To study the influence of different microembolism on left ventricular systolic synchronism in pigs by detecting the real-time dypyridamole stress contrast echocardiography (RT-MCE).Methods Eighteen miniature pigs were randomly divided into three groups and underwent microembolization injection procedure through the middle of anterior descending coronary artery with different numbers of microsphere injection,as:group A(dosage 50 thousands,3 pigs),group B (dosage 120 thousands,8 pigs) and group C (dosage 150 thousands,7 pigs).The peak values and the time-to-peak circumferential strain(Circ.Strain),radial velocity (Radial Vel.) and radial strain (Radial Strain) were obtained both at mitral valve level and papillary muscle level at left ventricle short axis views using two-dimensional speckle tracking imaging(STI)analyzed by Philips Q-Lab 8.1 workshop,respectively.Results No significant difference in the presence of contraction synchrony was observed using RT-MCE.The time-to-peak Circ.Strain of microembolism related segments were prolonged at 1 week after microembolism detecting with dypyridamole stress RT-MCE (P＜0.05,both intro-group and inter-group).While time-to-peak radial strain were extended since 6 hours after the intervention to 1 week after the procedure.Conclusions Dypyridamole stress RT-MCE can be used to measure the myocardial perfusion accurately.The elongation of time-to-peak circ.strain and radial strain were developed with time in microembolism related segments.
