国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2009年
7期
414-416
,共3页
功能性呼吸困难%呼吸中枢%负反馈机制%过度通气试验
功能性呼吸睏難%呼吸中樞%負反饋機製%過度通氣試驗
공능성호흡곤난%호흡중추%부반궤궤제%과도통기시험
Functional dyspnes%Respiratory center%Negative feedback mechanism%Hyperventilation test
目的 探讨功能性呼吸困难患者呼吸中枢负反馈机制特点.方法 临床诊断功能性呼吸困难12例,设立器质性疾病组和正常对照组各12例,分别检测各组过度通气试验前后屏气时间,数据行单因素方差分析.结果 功能性呼吸困难组过度通气试验前、后屏气时间分别为:(62.67±20.4)s与(42.08±22.20)s,过度通气后屏气时间较过度通气前屏气时间缩短.器质性疾病组、正常对照组则过度通气后屏气时间较过度通气前屏气时间延长.功能性呼吸困难组与器质性疾病组、正常对照组相比存在显著差异,P<0.001.结论 器质性疾病组及正常对照组过度通气试验后屏气时间延长,符合呼吸中枢负反馈机制,功能性呼吸困难组过度通气试验后屏气时间较过度通气前缩短,不符合呼吸中枢负反馈机制,考虑患者组呼吸中枢负反馈机制减弱或缺失.
目的 探討功能性呼吸睏難患者呼吸中樞負反饋機製特點.方法 臨床診斷功能性呼吸睏難12例,設立器質性疾病組和正常對照組各12例,分彆檢測各組過度通氣試驗前後屏氣時間,數據行單因素方差分析.結果 功能性呼吸睏難組過度通氣試驗前、後屏氣時間分彆為:(62.67±20.4)s與(42.08±22.20)s,過度通氣後屏氣時間較過度通氣前屏氣時間縮短.器質性疾病組、正常對照組則過度通氣後屏氣時間較過度通氣前屏氣時間延長.功能性呼吸睏難組與器質性疾病組、正常對照組相比存在顯著差異,P<0.001.結論 器質性疾病組及正常對照組過度通氣試驗後屏氣時間延長,符閤呼吸中樞負反饋機製,功能性呼吸睏難組過度通氣試驗後屏氣時間較過度通氣前縮短,不符閤呼吸中樞負反饋機製,攷慮患者組呼吸中樞負反饋機製減弱或缺失.
목적 탐토공능성호흡곤난환자호흡중추부반궤궤제특점.방법 림상진단공능성호흡곤난12례,설립기질성질병조화정상대조조각12례,분별검측각조과도통기시험전후병기시간,수거행단인소방차분석.결과 공능성호흡곤난조과도통기시험전、후병기시간분별위:(62.67±20.4)s여(42.08±22.20)s,과도통기후병기시간교과도통기전병기시간축단.기질성질병조、정상대조조칙과도통기후병기시간교과도통기전병기시간연장.공능성호흡곤난조여기질성질병조、정상대조조상비존재현저차이,P<0.001.결론 기질성질병조급정상대조조과도통기시험후병기시간연장,부합호흡중추부반궤궤제,공능성호흡곤난조과도통기시험후병기시간교과도통기전축단,불부합호흡중추부반궤궤제,고필환자조호흡중추부반궤궤제감약혹결실.
Objective To investigate the characteristics of negative feedback of respiratory center in patients with functional dyspnea.Methods Thirty-six subjects were divided into functional dyspnea group (n=12),organic disease group(n=12)and normal control group(n=12).Breath holding time(BHT)before and after hyperventilation test was compared among groups.Parameters were analysed with one-factor analysis of variance.Results BHT in functional dyspnea group was(62.67±20.4)seconds before hyperventilation and(42.08±22.20) seconds after hyperventilation.BHT was significantly shorter after hypervention than before hyperventilation in this group.However,BHT was longer after hyperVentilation than before hyperventilation in both organic disease group and normal control group.Functional dyspnea group showed a significant difference in BHT from organic disease and normal control group(P<0.001).Conclusions The longer BHT after hyperventilation in organic disease and normal control groups can be explained by the negative feedback mechanisms of respiratory center.But the shorter BHT after hyperventilation in functional dyspnea group is not in accordance with the feedback mechanisms of respiratory center and we consider that there may be weakening or loss of feedback mechanism in this group.
