CAJ | 학술논문

目的分析伴19p13异常的急性淋巴细胞白血病(ALL)患者的临床和实验室特征:方法对16例伴19p13异常的ALL患者的细胞形态学、免疫学、细胞遗传学和临床特点进行回顾性分析,并对t(1;19)组和der(19)组的临床和实验室资料进行对比分析.结果伴19p13异常的ALL占同期ALL的4.02%,其中t(1;19)(q23;p13)15例[平衡易位t(1;19)(q23;p13)8例,不平衡易位der(19)t(1;19)(q23;p13)7例],t(17;19)(q22;p13)1例,t(1;19)组的外周血门细胞汁数和骨髓原始幼稚淋巴细胞比例明显高于der(19)组,而der(19)组的预后较t(1;19)组好.结论 19p13异常是ALL的一个非随机的染色体改变;伴有该异常的ALL患者具有独特的I临床特征和小良预后.
목적 분석반19p13이상적급성림파세포백혈병(ALL)환자적림상화실험실특정:방법 대16례반19p13이상적ALL환자적세포형태학、면역학、세포유전학화림상특점진행회고성분석,병대t(1;19)조화der(19)조적림상화실험실자료진행대비분석.결과 반19p13이상적ALL점동기ALL적4.02%,기중t(1;19)(q23;p13)15례[평형역위t(1;19)(q23;p13)8례,불평형역위der(19)t(1;19)(q23;p13)7례],t(17;19)(q22;p13)1례,t(1;19)조적외주혈문세포즙수화골수원시유치림파세포비례명현고우der(19)조,이der(19)조적예후교t(1;19)조호.결론 19p13이상시ALL적일개비수궤적염색체개변;반유해이상적ALL환자구유독특적I림상특정화소량예후.
Objective To investigate the clinical and laboratory characteristics of patients with acute lymphoblastie leukemia (ALL) bearing 19p13 abnormalities. Methods The morphologic, immunophenotyp- ic, cytogenetie, and clinal features as well as prognosis of 16 ALL patients with 19p13 abnormalities were retrospectively analyzed. The clinical features and laboratory findings between t(1;19) and der(19) groups were compared. Results Sixteen (4.02%)out of 398 ALL patients had 19p13 abnormalities, among them 15 cases were t (1 ; 19) (q23 ; p 13) [balanced t (1 ; 19) (q23 ; p 13} in 8 and unbalanced der (19) t (1 ; 19) (q23 ;p13} in 7] and 1 case t(17;19)(q22;p13). The W BC count and blast cell number were higher in the t (1 ; 19) group. The prognosis was better in der(19) t(1 ; 19) group than in balanced translocation t(1 ; 19) group. Conclusion The 19p13 abnormality is one of the non-random chromosomal aberration in patients with ALL. ALL patients with 19p13 abnormalities have unique clinical features and poor prognosis.