CAJ | 학술논문

阿尔茨海默病是一种神经退行性疾病,其典型特征是进行性神经元缺失,迄今为止还没有一种药物和治疗方法对其彻底根治.随着干细胞技术与理论的发展和完善,阿尔茨海默病的治疗研究主要集中在神经干细胞移植方面.为避免免疫反应,最好用自体干细胞进行移植,而获取自体神经干细胞是非常困难的.与神经干细胞相比,间充质干细胞具有更广泛的来源,可以从肝脏、骨髓、脂肪等多种组织中获得,且具有多向分化潜能的特质,在一定诱导条件下可分化为骨、肌肉、脂肪等多种组织,其中脂肪间充质干细胞因其具有容易获得、对患者损伤小等特性而备受关注.新近研究显示,脂肪间充质干细胞具有神经分化潜能,预测其很可能在阿尔茨海默病治疗中发挥重要作用.
아이자해묵병시일충신경퇴행성질병,기전형특정시진행성신경원결실,흘금위지환몰유일충약물화치료방법대기철저근치.수착간세포기술여이론적발전화완선,아이자해묵병적치료연구주요집중재신경간세포이식방면.위피면면역반응,최호용자체간세포진행이식,이획취자체신경간세포시비상곤난적.여신경간세포상비,간충질간세포구유경엄범적래원,가이종간장、골수、지방등다충조직중획득,차구유다향분화잠능적특질,재일정유도조건하가분화위골、기육、지방등다충조직,기중지방간충질간세포인기구유용역획득、대환자손상소등특성이비수관주.신근연구현시,지방간충질간세포구유신경분화잠능,예측기흔가능재아이자해묵병치료중발휘중요작용.
Alzheimer's disease is an irreversible neurodegenerative disease characterized by progressive neuronal loss. To date, there has been no effective medicine or therapy for neurodegenerative disease. With development of stem cell technique and theory, neural stem cell transplantation has been found to be prospective in Alzheimer's disease treatment. However, it was challenged by the deficiency of autologous neural stem cell, which can bypass immunological barrier. Compared with neural stem cells, mesenchymal stem cells exhibit extensive resources, such as liver, bone marrow and adipose, and multiple differentiations into bone, muscle or adipose. Considering the easy access, the minor trauma to the patients, and the neuron differentiation potential of adipose derived mesenchymal stem cells (A-MSC), we hypothesize that A-MSC graft is a potential and innovative strategy for the treatment of Alzheimer's disease.