CAJ | 학술논문

目的探讨人绒毛膜促性腺激素(HCG)和促卵泡激素(FSH)联合治疗男性低促性腺激素性性腺功能减退症的有效性和安全性.方法 29例男性低促性腺激素性性腺功能减退症23例,Kallmann综合征6例.治疗方案:采用联合HCG 2000 IU,2次/周;FSH 75 IU,3次/周,肌肉注射,连续用药至少3个月. 结果治疗后所有患者体力改善,体质增强;22例患者出现胡须、阴毛和(或)腋毛.睾丸体积治疗前(2.68±1.44)ml,治疗后(8.93±3.24)ml(P<0.01);促卵泡激素(FSH)、促黄体激素(LH)和睾酮(T)水平有所提高(P<0.05);12例患者出现遗精现象,8例有精子生成.结论对男性低促性腺激素性性腺功能减退症,用HCG和FSH治疗能促进青春期第二性征发育,并可使部分睾丸恢复产生雄激素和生成精子功能.
목적 탐토인융모막촉성선격소(HCG)화촉란포격소(FSH)연합치료남성저촉성선격소성성선공능감퇴증적유효성화안전성.방법 29례남성저촉성선격소성성선공능감퇴증23례,Kallmann종합정6례.치료방안:채용연합HCG 2000 IU,2차/주;FSH 75 IU,3차/주,기육주사,련속용약지소3개월. 결과치료후소유환자체력개선,체질증강;22례환자출현호수、음모화(혹)액모.고환체적치료전(2.68±1.44)ml,치료후(8.93±3.24)ml(P<0.01);촉란포격소(FSH)、촉황체격소(LH)화고동(T)수평유소제고(P<0.05);12례환자출현유정현상,8례유정자생성.결론 대남성저촉성선격소성성선공능감퇴증,용HCG화FSH치료능촉진청춘기제이성정발육,병가사부분고환회복산생웅격소화생성정자공능.
Objective To evaluate the efficacy and safety of human chorionic gonadotrophin (HCG) and follicle stimulating hormone (FSH) for treatment of patients with hypogonadotropic hypogonadism.Methods Total of 29 male patients including 23 hypogonadotropic hypogonadism patients and 6 Kallmann's syndrome patients were enrolled in the study.Therapeutic project:HCG 2000 IU 2 times/week combining with FSH 75 IU,3 times/week by intramuscular injection for at least 3 months.Results Three months after treatment,all patients felt their physical strength more strong.Of them,22 patients appeared beard,pubic hair and (or) armpit hair.The volume of testicle was (2.68±1.44) ml and (8.93±3.24) ml before and after treatment respectively (P＜0.01).The levels of follicle stimulating hormone (FSH),luteinizing hormone (LH) and testosterone (T) were increased (P＜0.05) after treatment.Of them,12 patients appeared nocturnal emission and 8 patients had sperm.Conclusion For patients with hypogonadotropic hypogonadism,HCG combining with FSH might promote secondary sexual characteristics,and recover the testosterone production and spermatogenesis of testicle.