CAJ | 학술논문

目的探讨诱导痰及末梢血嗜酸粒细胞(EOS)比例、诱导痰嗜酸粒细胞阳离子蛋白(ECP)水平在支气管哮喘（简称哮喘）发病不同时期的变化及应用价值。方法检测哮喘发作期40例（发作组）、哮喘缓解期48例（缓解组）、40名正常健康体检者（对照组）的诱导痰及末梢血EOS占白细胞百分比，同时分别测定痰ECP。结果 ①末梢血中EOS比例：哮喘发作期高于正常对照组(t =3.685 7，P＜0.001),差异具有统计学意义。而哮喘发作期高于缓解期(t =1.836 3，P＞0.05)，缓解期高于正常对照组(t =1.8602，P＞0.05)，但差异无统计学意义。②痰EOS比例：哮喘发作期高于缓解期和正常对照组（t =9.5776,18.305，P值均＜0.001），缓解期高于正常对照组(t =15.463,P＜0.001)，差异均具有非常显著的统计学意义。③痰ECP水平：哮喘发作期高于缓解期和正常对照组(t =7.331 3，12.579，P值均＜0.001)，缓解期高于正常对照组(t=8.8297，P＜0.001),差异均具有非常显著的统计学意义。结论①哮喘急性发作期和缓解期诱导痰EOS比例显著高于末梢血EOS比例，应用检测EOS比例评价哮喘的炎症程度，诱导痰优于末梢血；②诱导痰ECP水平和痰EOS比例在哮喘的诊断中具有同样的价值，可作为监测和指导哮喘抗炎治疗的指标之一。
목적탐토유도담급말소혈기산립세포(EOS)비례、유도담기산립세포양리자단백(ECP)수평재지기관효천（간칭효천）발병불동시기적변화급응용개치。방법검측효천발작기40례（발작조）、효천완해기48례（완해조）、40명정상건강체검자（대조조）적유도담급말소혈EOS점백세포백분비，동시분별측정담ECP。결과 ①말소혈중EOS비례：효천발작기고우정상대조조(t =3.685 7，P＜0.001),차이구유통계학의의。이효천발작기고우완해기(t =1.836 3，P＞0.05)，완해기고우정상대조조(t =1.8602，P＞0.05)，단차이무통계학의의。②담EOS비례：효천발작기고우완해기화정상대조조（t =9.5776,18.305，P치균＜0.001），완해기고우정상대조조(t =15.463,P＜0.001)，차이균구유비상현저적통계학의의。③담ECP수평：효천발작기고우완해기화정상대조조(t =7.331 3，12.579，P치균＜0.001)，완해기고우정상대조조(t=8.8297，P＜0.001),차이균구유비상현저적통계학의의。결론①효천급성발작기화완해기유도담EOS비례현저고우말소혈EOS비례，응용검측EOS비례평개효천적염증정도，유도담우우말소혈；②유도담ECP수평화담EOS비례재효천적진단중구유동양적개치，가작위감측화지도효천항염치료적지표지일。
Objective To investigate the changes and value of induced sputum and peripheral blood eosinophils (EOS) ratio, induced sputum eosinophil cationic protein (ECP) levels in the pathogenesis of different periods in patients with bronchial asthma (asthma). Methods The induced sputum and peripheral blood EOS percentage of total white blood cells, and sputum ECP were measured in bronchial asthma in 40 patients (group attack), asthma remission in 48 patients (remission), 40 normal healthy persons (control group). Results ①The proportion of peripheral blood EOS: asthma is higher than the control group (t =3.685 7, P ＜0. 01 ), difference was statistically significant. And asthma is higher than the remission( t =1.836 3, P ＞0.05), remission is higher than the control group( t =1.860 2, P＞0.05), but the difference was not statistically significant. ②Sputum EOS ratio:asthma is higher than the remission and normal control group( t =9.577 6,18.305, P ＜0.01),remission is higher than the control group (t=15.463, P ＜0.01), the differences were very significant statistically significant. ③ Sputum ECP levels:asthma is higher than the remission and normal control group ( t =7.3313, 12.579, P ＜0.01), remission is higher than the control group ( t =8.829 7, P ＜0.01), the differences were very significant statistical significance. Conclusions ①Proportion EOS induced sputum was significantly higher than the proportion of peripheral blood in bronchial asthma in acute exacerbation and remission, induced sputum is better than the proportion of peripheral blood EOS application testing evaluation of the degree of inflammation of asthma. ②ECP levels in induced sputum and sputum EOS ratio is of equal value in the diagnosis of asthma can be used as an indicator of anti-inflammatory treatment of bronchial asthma monitoring and guidance.