CAJ | 학술논문

目的探讨急性肝功能衰竭患者等待肝移植期间应用分子吸附循环系统的治疗效果.方法本组共有16例急性肝功能衰竭患者在等待肝移植期间接受了分子吸附循环系统治疗.结果 16例患者经治疗临床症状及体征明显改善:凝血酶原时间、总胆汁酸、丙氨酸转氨酶、天冬氨酸转氰酶、肌酐和血氨水平明显降低(P＜0.05);肿瘤坏死因子α、一氧化氮和白细胞介素10等细胞因子水平有所下降,但无统计学意义(P＞0.05);序贯性脏器衰竭评估的计分由9.91±1.09降至6.64±1.76,Glascow昏迷评分由7.29±2.06升至13.26±2.14.16例患者中14例成功过渡到肝移植治疗,13例痊愈出院.治疗成功率为81.25%.结论分子吸附循环系统是治疗肝功能衰竭安全而有效的辅助方法,帮助急性肝功能衰竭患者顺利渡过肝移植等待期.
목적 탐토급성간공능쇠갈환자등대간이식기간응용분자흡부순배계통적치료효과.방법 본조공유16례급성간공능쇠갈환자재등대간이식기간접수료분자흡부순배계통치료.결과 16례환자경치료림상증상급체정명현개선:응혈매원시간、총담즙산、병안산전안매、천동안산전청매、기항화혈안수평명현강저(P＜0.05);종류배사인자α、일양화담화백세포개소10등세포인자수평유소하강,단무통계학의의(P＞0.05);서관성장기쇠갈평고적계분유9.91±1.09강지6.64±1.76,Glascow혼미평분유7.29±2.06승지13.26±2.14.16례환자중14례성공과도도간이식치료,13례전유출원.치료성공솔위81.25%.결론 분자흡부순배계통시치료간공능쇠갈안전이유효적보조방법,방조급성간공능쇠갈환자순리도과간이식등대기.
Objective To study molecular adsorbent recycling system (MARS) in the treatment of patients with acute liver failure waiting for liver transplantation. Methods The effects of MARS artificial liver treatments in 16 cases were reviewed. Results There was a remarkable improvement in clinical symptoms and physical signs after MARS treatment, including significant decrease in prothrombin time, total bile acid, level of alanine aminotransferase, aspartate aminotransferase, creatinine, and blood ammonia (P＜0.05＝;There was no statistical change in NO,TNF-α and IL-10(P＞0.05).Sequential organ failure assessment(SOFA)score decreased from 9.91±1.09 to 6.64±1.76 and Glascow coma score increased from 7.29±2.06 to 13.26±2.14.Fourteen patients were tided over to liver transplantation among them 13 patients survived and were successfully discharged from the hospital. The survival rate was 89.5%.Conclusion MARS is a safe and effective assistant device in bridging acute liver failure patients to liver transplantation.