中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2010年
9期
744-747
,共4页
肝素,低分子量%静脉血栓形成%直肠肿瘤%围手术期
肝素,低分子量%靜脈血栓形成%直腸腫瘤%圍手術期
간소,저분자량%정맥혈전형성%직장종류%위수술기
Heparin,low-molecular-weight%Venous thrombosis%Rectal neoplasms%Perioperative period
目的 评价围手术期应用抗凝药物预防直肠癌术后下肢深静脉血栓形成(deep vein thrombosis,DVT)的疗效和安全性.方法 回顾性分析2006年1月至2009年6月收治的96例直肠癌手术患者的临床资料,分为两组(非抗凝组48例,抗凝组48例).抗凝组围手术期应用低分子肝素钙;非抗凝组围手术期未用低分子肝素钙.结果 抗凝组DVT的发生率为4%,明显低于非抗凝组(19%)(x2=5.031,P＜0.05);抗凝组术后住院时间为(12±3)d,明显少于非抗凝组[(22±6)d](t=10.328,P＜0.01).两组手术时间、术中出血量及术后引流血量,手术前后外周血小板计数,手术前后凝血酶原时间及部分凝血酶原时间,术后下肢深静脉血栓形成的开始时间,继发不良反应,术后主要并发症发生率及死亡率两组间比较,差异均无统计学意义(均P＞0.05).结论 抗凝药物围手术期应用可安全有效地预防直肠癌根治术后下肢深静脉血栓形成.
目的 評價圍手術期應用抗凝藥物預防直腸癌術後下肢深靜脈血栓形成(deep vein thrombosis,DVT)的療效和安全性.方法 迴顧性分析2006年1月至2009年6月收治的96例直腸癌手術患者的臨床資料,分為兩組(非抗凝組48例,抗凝組48例).抗凝組圍手術期應用低分子肝素鈣;非抗凝組圍手術期未用低分子肝素鈣.結果 抗凝組DVT的髮生率為4%,明顯低于非抗凝組(19%)(x2=5.031,P＜0.05);抗凝組術後住院時間為(12±3)d,明顯少于非抗凝組[(22±6)d](t=10.328,P＜0.01).兩組手術時間、術中齣血量及術後引流血量,手術前後外週血小闆計數,手術前後凝血酶原時間及部分凝血酶原時間,術後下肢深靜脈血栓形成的開始時間,繼髮不良反應,術後主要併髮癥髮生率及死亡率兩組間比較,差異均無統計學意義(均P＞0.05).結論 抗凝藥物圍手術期應用可安全有效地預防直腸癌根治術後下肢深靜脈血栓形成.
목적 평개위수술기응용항응약물예방직장암술후하지심정맥혈전형성(deep vein thrombosis,DVT)적료효화안전성.방법 회고성분석2006년1월지2009년6월수치적96례직장암수술환자적림상자료,분위량조(비항응조48례,항응조48례).항응조위수술기응용저분자간소개;비항응조위수술기미용저분자간소개.결과 항응조DVT적발생솔위4%,명현저우비항응조(19%)(x2=5.031,P＜0.05);항응조술후주원시간위(12±3)d,명현소우비항응조[(22±6)d](t=10.328,P＜0.01).량조수술시간、술중출혈량급술후인류혈량,수술전후외주혈소판계수,수술전후응혈매원시간급부분응혈매원시간,술후하지심정맥혈전형성적개시시간,계발불량반응,술후주요병발증발생솔급사망솔량조간비교,차이균무통계학의의(균P＞0.05).결론 항응약물위수술기응용가안전유효지예방직장암근치술후하지심정맥혈전형성.
Objective To evaluate curative effect and safety of anticoagulant drugs used in perioperative period to prevent deep vein thrombosis (DVT) after rectal carcinoma surgery. Methods Clinical data of 96 postoperative rectal carcinoma cases from January 2006 to June 2009 were analyzed retrospectively.These cases were divided into two groups:48 cases in nonanticoagulant group and 48 cases in anticoagulant group.After radical operation of rectal carcinoma,low molecular heparin calcium was injected subcutaneously daily for 8 consecutive days beginning the day before surgery in anticoagulant group. Results Incidence of DVP in anticoagulant group (4%) was significantly lower than that in noncoagulant group (19%) (x2 = 5.031,P ＜ 0.05).Postoperative hospitalization time in anticoagulant group [(12 ± 3) d] was significantly shorter than that of nonanticoagulant group [(22 ± 6) d] (t = 10.328,P＜ 0.01).There were no significant differences between two groups in operative time,blood loss and postoperative blood drainage,peripheral blood platelet counts before and after operation,prothombin time and active part thrombin time before and after operation,the time when postoperative DVT developes;secondary adverse reactions; postoperative major complication rate and mortality (all P ＞ 0.05). Conclusion Anticoagulant drugs used in perioperative period is safe and effective in prevention of deep vein thrombosis in lower limbs after radical operation of rectal carcinoma.
