中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2011年
12期
1265-1268
,共4页
原发性闭角型青光眼%晶状体%发病机制
原髮性閉角型青光眼%晶狀體%髮病機製
원발성폐각형청광안%정상체%발병궤제
Primary angle closure glaucoma%Lens%Pathogenesis
目的 探讨晶状体在原发性闭角型青光眼(primary angle closure glaucoma,PACG)发病机制中的作用.方法 采用超声生物显微镜、B超、和计算机图像处理软件对急性PACG患者40例(80只眼)、慢性PACG患者40例(80只眼)和正常人40名(80只眼)的眼前节参数进行测量和计算,对晶状体参数与前房深度和房角参数的相关性进行分析.结果急性和慢性PACG组与正常组比较,晶状体厚(包括中央部和周边部厚度)、前表面曲率大、相对位置偏前,差异有统计学意义(P＜0.01)；急性、慢性PACG组与正常组的晶状体直径、后表面曲率半径和体积进行组间比较,差异无统计学意义(P＞0.05)；急性和慢性PACG组的前房深度、房角开放距离和小梁虹膜夹角分别与晶状体前表面曲率半径和相对位置呈中度正相关(P＜0.01).结论 PACG的发病与晶状体解剖结构异常有关,包括晶状体厚,前表面曲率大和相对位置偏前.晶状体直径、体积和后表面曲率与发病未见相关关系.与急性PACG相比,慢性PACG眼前段拥挤程度相对较轻.
目的 探討晶狀體在原髮性閉角型青光眼(primary angle closure glaucoma,PACG)髮病機製中的作用.方法 採用超聲生物顯微鏡、B超、和計算機圖像處理軟件對急性PACG患者40例(80隻眼)、慢性PACG患者40例(80隻眼)和正常人40名(80隻眼)的眼前節參數進行測量和計算,對晶狀體參數與前房深度和房角參數的相關性進行分析.結果急性和慢性PACG組與正常組比較,晶狀體厚(包括中央部和週邊部厚度)、前錶麵麯率大、相對位置偏前,差異有統計學意義(P＜0.01)；急性、慢性PACG組與正常組的晶狀體直徑、後錶麵麯率半徑和體積進行組間比較,差異無統計學意義(P＞0.05)；急性和慢性PACG組的前房深度、房角開放距離和小樑虹膜夾角分彆與晶狀體前錶麵麯率半徑和相對位置呈中度正相關(P＜0.01).結論 PACG的髮病與晶狀體解剖結構異常有關,包括晶狀體厚,前錶麵麯率大和相對位置偏前.晶狀體直徑、體積和後錶麵麯率與髮病未見相關關繫.與急性PACG相比,慢性PACG眼前段擁擠程度相對較輕.
목적 탐토정상체재원발성폐각형청광안(primary angle closure glaucoma,PACG)발병궤제중적작용.방법 채용초성생물현미경、B초、화계산궤도상처리연건대급성PACG환자40례(80지안)、만성PACG환자40례(80지안)화정상인40명(80지안)적안전절삼수진행측량화계산,대정상체삼수여전방심도화방각삼수적상관성진행분석.결과급성화만성PACG조여정상조비교,정상체후(포괄중앙부화주변부후도)、전표면곡솔대、상대위치편전,차이유통계학의의(P＜0.01)；급성、만성PACG조여정상조적정상체직경、후표면곡솔반경화체적진행조간비교,차이무통계학의의(P＞0.05)；급성화만성PACG조적전방심도、방각개방거리화소량홍막협각분별여정상체전표면곡솔반경화상대위치정중도정상관(P＜0.01).결론 PACG적발병여정상체해부결구이상유관,포괄정상체후,전표면곡솔대화상대위치편전.정상체직경、체적화후표면곡솔여발병미견상관관계.여급성PACG상비,만성PACG안전단옹제정도상대교경.
Objective To research lens parameters in the pathogenesis of primary angle closure glaucoma (PACG).Methods Of 40 acute PACG in-patients (80 eyes),40 chronic PACG ones (80eyes) and 40 healthy individuals with wide chamber angle (80 eyes),parameters of ocular anterior segment were calculated and correlation analyzed among the lens parameters,anterior chamber depth and parameters of anterior chamber angle by B ultrasound,self-developed computer image processing software and ultrasound biomicroscope (UBM).Results Compared with the normal group,PACG had thicker lens,steeper anterior surface curvature of lens and relatively more anterior lens position,among which there were statistically significant differences (P ＜0.01),but no significant differences among the lens diameter,lens volume and the curvature radius of posterior lens surface (P ＞0.05).For PACG,both the curvature radius of anterior lens surface and relative position of lens had moderately positive correlation with anterior chamber depth,angle open distance at 500μ m and trabecular iris angle (TIA)(P ＜0.01).Conclusions The PACG pathogenesis show relevance to the abnormalities of lens anatomical structures,including the thicker lens,steeper curvature of anterior lens surface,and the relative more anterior position of lens.Lens diameter,its volume and its curvature of posterior surface do not confirm correlation with PACG.Compare with that of acute PACG,anterior segment of chronic PACG crowd relatively less.
