CAJ | 학술논문

细胞凋亡是在生理或病理条件下,为维持内环境的稳定的一种程序性细胞死亡.诱导细胞凋亡的因素可分为物理性、化学性和生物性因素.很多实验数据表明氧化应激在细胞凋亡的发生过程中具有重要作用.各种活性氧类物质如超氧阴离子、过氧化氢、羟自由基和一氧化氮均与细胞凋亡的发生有关.但是活性氧类物质诱导凋亡发生的机理尚未阐明.本综述在对细胞凋亡和氧化应激描述的基础上着重讨论活性氧类物质诱导细胞凋亡发生的可能机理.在以后的研究中,将着重于探讨化学物质通过产生活性氧类物质而影响细胞凋亡的机理及建立相关的生物标志物.
세포조망시재생리혹병리조건하,위유지내배경적은정적일충정서성세포사망.유도세포조망적인소가분위물이성、화학성화생물성인소.흔다실험수거표명양화응격재세포조망적발생과정중구유중요작용.각충활성양류물질여초양음리자、과양화경、간자유기화일양화담균여세포조망적발생유관.단시활성양류물질유도조망발생적궤리상미천명.본종술재대세포조망화양화응격묘술적기출상착중토론활성양류물질유도세포조망발생적가능궤리.재이후적연구중,장착중우탐토화학물질통과산생활성양류물질이영향세포조망적궤리급건립상관적생물표지물.
Apoptosis is a genetically programmed active cell death process for maintaining homeostasis under phy- siological conditions and for responding to various stimuli. Apoptosis can be induced by a wide variety of physical, chemical and biological stimuli. There is compelling evidence for the central role of oxidative stress in the apoptotic process. Various reactive oxygen species (ROS) and nitrogen species such as superoxide anion, hydrogen peroxide, hydroxyl radical and nitric oxide are involved in apoptosis. But the mechanism through which ROS plays an important role in inducing apoptosis is not fully understood. This review will address some of the current paradigms for oxidative stress and apoptosis, and discuss the possible mechanism by which oxidants can modulate the apoptotic pathway. In the future research, the research will emphasized on the mechanisms of apoptosis induced by chemicals and the regulatory effect of ROS involved in this process, moreover, the finding will provide new insights into the related biomarkers.