CAJ | 학술논문

采用腺嘌呤致大鼠慢性肾衰(CRF)的模型，研究丹参多酚酸盐对CRF大鼠肾功能及内源性内皮素释放的影响.结果表明，在CRF模型中，大鼠血清尿素氮，肌肝水平，血浆内皮素水平及肾皮质钙含量均明显升高；丹参多酚酸盐5,10，15mg.kg-1，ip连续给药14d，则使CRF大鼠的血清尿素氮,肌肝水平降低，丹参多酚酸盐10mg.kg-1组的血清尿素氮已与正常对照组无显著差异（P>0.05）.另外，与CRF大鼠相比，丹参多酚酸盐5，10，15mg.kg-1组血浆内皮素水平及肾皮质钙含量均明显降低，10mg.kg-1组与15mg.kg-1组无显著差异，10mg.kg-1组内皮素水平及肾皮质钙含量较模型组分别降低了59%，51%.形态及定量检测肾小管平均截面积，肾小球平均体积的结果表明，丹参多酚酸盐10mg.kg-1组能减少肾组织结晶沉淀物，减轻肾小管，肾小球损伤程度，延缓肾小球基底膜增厚.结果提示，丹参多酚酸盐能明显改善肾功能，其机理可能与其抑制内皮素的释放有关.
채용선표령치대서만성신쇠(CRF)적모형，연구단삼다분산염대CRF대서신공능급내원성내피소석방적영향.결과표명，재CRF모형중，대서혈청뇨소담，기간수평，혈장내피소수평급신피질개함량균명현승고；단삼다분산염5,10，15mg.kg-1，ip련속급약14d，칙사CRF대서적혈청뇨소담,기간수평강저，단삼다분산염10mg.kg-1조적혈청뇨소담이여정상대조조무현저차이（P>0.05）.령외，여CRF대서상비，단삼다분산염5，10，15mg.kg-1조혈장내피소수평급신피질개함량균명현강저，10mg.kg-1조여15mg.kg-1조무현저차이，10mg.kg-1조내피소수평급신피질개함량교모형조분별강저료59%，51%.형태급정량검측신소관평균절면적，신소구평균체적적결과표명，단삼다분산염10mg.kg-1조능감소신조직결정침정물，감경신소관，신소구손상정도，연완신소구기저막증후.결과제시，단삼다분산염능명현개선신공능，기궤리가능여기억제내피소적석방유관.
The effects of salvianolate on renal function and endogenousendothelin release were studied in a rat model of adenine-induced chronic renal failure(CRF). CRF rats were administrated ip for 14 d with normal saline in control, salvianolate 5, 10, 15 mg.kg-1 in treated animal, respectively. The renal function was improved dose-dependently by salvianolate in decreasing both serum creatinine and urea nitrogen. Besides, the plasma endothelin, calcium content of renal cortex, the mean glomerular volume(GV), the basement membrane thickness, and the mean tubular area(TA) in salvianolate group were compared with that of CRF animal. The results showed that plasma endothelin and calcium content of renal cortex were reduced, the increase in GV, the rise of the basement membrane thickness, the decreased of TA were also inhibited by salvianolate. The results indicate that salvianolate improve the renal function and prevent the development of renal failure, which may be related to the inhibition of endogenous endothelin release.