CAJ | 학술논문

目的: 研究槲皮黄素灌胃后对大鼠肝静脉血浆代谢组学的变化及其意义. 方法:大鼠按40 mg/kg剂量槲皮黄素灌胃,分别于灌胃前(0 h)、灌胃后0.5、1、2和4 h采集肝静脉血液制备血浆,以1H核磁共振(1H NMR)分析代谢组变化. 结果: 槲皮黄素灌胃后,大鼠肝静脉血浆代谢组呈聚类分布,葡萄糖含量下降,β-羟丁酸、琥珀酸和丙酮酸等水平升高. 结论: 槲皮黄素对大鼠肝代谢具有显著影响,主要表现为葡萄糖分解增强,酮体生成增加.
목적: 연구곡피황소관위후대대서간정맥혈장대사조학적변화급기의의. 방법:대서안40 mg/kg제량곡피황소관위,분별우관위전(0 h)、관위후0.5、1、2화4 h채집간정맥혈액제비혈장,이1H핵자공진(1H NMR)분석대사조변화. 결과: 곡피황소관위후,대서간정맥혈장대사조정취류분포,포도당함량하강,β-간정산、호박산화병동산등수평승고. 결론: 곡피황소대대서간대사구유현저영향,주요표현위포도당분해증강,동체생성증가.
Objective: To investigate the effects of quercetin on hepatic vein metabolic profiles in rats. Methods: Male Wistar rats were administrated orally with 40 mg/kg quercetin. Hepatic vein plasma was collected at 0 h, 0.5 h, 1 h, 2 h and 4 h respectively after administration and analyzed by 1H NMR. Results: The identifiable biochemical effects associated with quercetin dosing included decreased plasma concentration of glucose and increased plasma concentration of succinate,β-hydroxybutyrate and pyruvate. Conclusion: Quercetin changes hepatic metabolism in rats, manifested mainly as increased glucose catabolism and production of ketone bodies.