CAJ | 학술논문

本文研究了金耳菌丝体多糖(TMP)对实验性2型糖尿病大鼠血糖、血脂、胰岛素敏感性和抗氧化能力的影响.采用烟酰胺,链脲佐菌素和高脂饲料诱导2型糖尿病大鼠模型,以50和100 mg/(kg·d)剂量的TMP连续灌胃48 d,监测血糖,测定血清胰岛素、体重、脂代谢及抗氧化系统部分相关指标,并进行口服糖耐量实验.结果显示,TMP可明显降低2型糖尿病大鼠的血清葡萄糖、总胆固醇、甘油三酯和丙二醛水平,并极显著提高受试模型鼠的胰岛素敏感指数,血清超氧化物歧化酶活性和肝脏过氧化氢酶活性.此外,TMP能显著降低糖耐量实验中糖负荷后120 min时糖尿病大鼠的血糖含量.上述结果表明TMP可有效降低实验性2型糖尿病大鼠的血糖水平,纠正脂代谢紊乱,改善胰岛素抵抗,增强抗氧化能力.
본문연구료금이균사체다당(TMP)대실험성2형당뇨병대서혈당、혈지、이도소민감성화항양화능력적영향.채용연선알,련뇨좌균소화고지사료유도2형당뇨병대서모형,이50화100 mg/(kg·d)제량적TMP련속관위48 d,감측혈당,측정혈청이도소、체중、지대사급항양화계통부분상관지표,병진행구복당내량실험.결과현시,TMP가명현강저2형당뇨병대서적혈청포도당、총담고순、감유삼지화병이철수평,병겁현저제고수시모형서적이도소민감지수,혈청초양화물기화매활성화간장과양화경매활성.차외,TMP능현저강저당내량실험중당부하후120 min시당뇨병대서적혈당함량.상술결과표명TMP가유효강저실험성2형당뇨병대서적혈당수평,규정지대사문란,개선이도소저항,증강항양화능력.
The present study was designed to evaluate the effects of crude polysaecharides extracted from Tremella aurantialba mycelia (TMP) on serum glucose, insulin sensitivity,lipid profiles and antioxidant parameters in nicotinamide and streptozotocin (STZ) -induced type 2-like diabetic rats.Type 2-like diabetes in rat was induced by nicotinamide, STZ and high fat diet.50 and 100 mg/(kg·d) TMP were fed by intragastric administration to diabetic rats once a day lasting for 48 days.In this study,we focused on measuring the change of serum glucose,insulin,lipid profiles,antioxidant pa-rameters and body weight to evaluate anti-diabetic effect of 'IMP.Moreover,effect of TMP on oral glucose tolerance test (OGTT) was been investigated.Results showed that administration of TMP significantly lowered the fasting serum glu-ease,total cholesterol (TC) ,triglycerides (TG) and malondialdehyde (MDA) levels in type 2-like diabetic rats.Mean-while,TMP also markedly increased the insulin sensitivity index (ISI) and activities of serum superoxide dismutase (SOD) and hepatic eatalase (CAT).In addition, TMP supplement significantly attenuated the elevated blood glucose levels of diabetic rats after 120 min of glucose loading in oral glucose tolerance test.These findings suggested that TMP might have hypoglycemic,hypolipidemic and antioxidant effects in nicotinamide-STZ induced type 2-like diabetic rats.Furthermore, TMP might improve insulin resistance in diabetic rats.