国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
13期
24-26
,共3页
胃癌%分期%生存素%生存分析%相关性分析
胃癌%分期%生存素%生存分析%相關性分析
위암%분기%생존소%생존분석%상관성분석
Gastric carcinoma%Stage%Survivin%Survival time%Correlation analysis
目的 探讨不同分期胃癌患者生存素(survivin)的含量与及生存期长短是否具有相关性.方法 分别收集22例初次确诊早期胃癌患者及16例进展期胃癌患者的胃粘膜活检组织,用免疫组化法检测胃粘膜生存素的含量;对以上患者进行为期5年的生存期观察.分别用Kaplan-Meier进行生存分析,用Spearman法分析survivin含量与生存期长短的相关性.结果 早期胃癌患者survivin表达强度明显低于进展期患者(Z=-2.137,P=0.033).早期胃癌患者的1年、3年及5年累计生存率分别为100.0%、63.6%及23.4%,中位生存期为42个月;进展期胃癌患者生存率分别为87.5%、22.5%及0.0%,中位生存期为24个月;两组的生存率差异具有统计学意义(χ2=14.144,P=0.000);38例患者的survivin表达强度与生存时间呈负相关性(相关系数C=0.367,P=0.023).结论 Survivin的表达强度与胃癌的分期有关,并且与存活期的呈负相关性,但该结论 有待大样本的研究进一步验证.
目的 探討不同分期胃癌患者生存素(survivin)的含量與及生存期長短是否具有相關性.方法 分彆收集22例初次確診早期胃癌患者及16例進展期胃癌患者的胃粘膜活檢組織,用免疫組化法檢測胃粘膜生存素的含量;對以上患者進行為期5年的生存期觀察.分彆用Kaplan-Meier進行生存分析,用Spearman法分析survivin含量與生存期長短的相關性.結果 早期胃癌患者survivin錶達彊度明顯低于進展期患者(Z=-2.137,P=0.033).早期胃癌患者的1年、3年及5年纍計生存率分彆為100.0%、63.6%及23.4%,中位生存期為42箇月;進展期胃癌患者生存率分彆為87.5%、22.5%及0.0%,中位生存期為24箇月;兩組的生存率差異具有統計學意義(χ2=14.144,P=0.000);38例患者的survivin錶達彊度與生存時間呈負相關性(相關繫數C=0.367,P=0.023).結論 Survivin的錶達彊度與胃癌的分期有關,併且與存活期的呈負相關性,但該結論 有待大樣本的研究進一步驗證.
목적 탐토불동분기위암환자생존소(survivin)적함량여급생존기장단시부구유상관성.방법 분별수집22례초차학진조기위암환자급16례진전기위암환자적위점막활검조직,용면역조화법검측위점막생존소적함량;대이상환자진행위기5년적생존기관찰.분별용Kaplan-Meier진행생존분석,용Spearman법분석survivin함량여생존기장단적상관성.결과 조기위암환자survivin표체강도명현저우진전기환자(Z=-2.137,P=0.033).조기위암환자적1년、3년급5년루계생존솔분별위100.0%、63.6%급23.4%,중위생존기위42개월;진전기위암환자생존솔분별위87.5%、22.5%급0.0%,중위생존기위24개월;량조적생존솔차이구유통계학의의(χ2=14.144,P=0.000);38례환자적survivin표체강도여생존시간정부상관성(상관계수C=0.367,P=0.023).결론 Survivin적표체강도여위암적분기유관,병차여존활기적정부상관성,단해결론 유대대양본적연구진일보험증.
Objective To explore the correlation between Survivin and survival time in patients with early and progression gastric carcinoma.Methods the data of gastric-mucosa tissue biopsy in 22 patients with progression gastric carcinoma and 16 patients with early gastric carcinoma were collected and the surviving levels of the gastric mucosas were detected by immunohistochemical method.The survival time of the patients were observed through a 5-year follow-up and analyzed through Kaplan-Meier method.The correlation between survivin and survival time was analyzed by Spearman method.Results Survivin in early gastric carcinoma was obviously lower than that of progression ones,and their difference was statistically significant(Z=-2.137,P=0.033),The accumulative survival rates of one,three and five year in early gastric carcinoma patients were 100.0%,63.6% and 23.4%,respectively,and mean of survival time was 42 months;Whereas the accumulative survival rates of one,three and five year was 87.5%,22.5%,0.0%,respectively and the mean of survival time was 24 months in progression gastric carcinoma patients.The difference of two groups was statistically significant(χ2=14.144,P=0.000).Survivin and survival time showed negative correlation(C=-0.367,P=0.023)Conclusion The contents of survivin were closely related to the different stage of gastric carcinoma,and there was a negative correlation between survivin and survival time,which needs large sample and multicentre study to confirm the result.
