中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2009年
2期
227-228
,共2页
癌,肝细胞%血管内皮生长因子%肿瘤坏死因子-α
癌,肝細胞%血管內皮生長因子%腫瘤壞死因子-α
암,간세포%혈관내피생장인자%종류배사인자-α
Carcinoma,hepatocellular%Vascular endothelial growth factor%Tumor necrosis factor-α
目的 通过检测原发性肝癌患者血清中血管内皮生长因子(VEGF)和肿瘤坏死因子(TNF-α)的水平变化,探讨其在肝癌发生发展及转移中的临床意义.方法 采用ELISA法检测87例确诊为原发性肝癌患者血清VEGF和TNF-α水平,同时测定10例健康人血清作为对照.结果 原发性肝癌患者血清VEGF和TNF-α水平明显增高[(586.38±148.21)ng/L,(178.45±32.15)ng/L],与对照组[(217.62+94.14)ng/L,(19.35±4.27)ng/L]相比差异均有统计学意义(P＜0.01);此外,合并肝炎病毒感染或发生转移的肝癌患者VEGF和TNF-α水平均明显高于非肝炎肝癌和未转移组肝癌患者,差异有统计学意义(P＜0.01).结论 原发性肝癌患者血清VEGF和TNF-α水平与肝癌病变发展及转移有一定相关性,对临床综合治疗和判断预后可能具有重要指导意义.
目的 通過檢測原髮性肝癌患者血清中血管內皮生長因子(VEGF)和腫瘤壞死因子(TNF-α)的水平變化,探討其在肝癌髮生髮展及轉移中的臨床意義.方法 採用ELISA法檢測87例確診為原髮性肝癌患者血清VEGF和TNF-α水平,同時測定10例健康人血清作為對照.結果 原髮性肝癌患者血清VEGF和TNF-α水平明顯增高[(586.38±148.21)ng/L,(178.45±32.15)ng/L],與對照組[(217.62+94.14)ng/L,(19.35±4.27)ng/L]相比差異均有統計學意義(P＜0.01);此外,閤併肝炎病毒感染或髮生轉移的肝癌患者VEGF和TNF-α水平均明顯高于非肝炎肝癌和未轉移組肝癌患者,差異有統計學意義(P＜0.01).結論 原髮性肝癌患者血清VEGF和TNF-α水平與肝癌病變髮展及轉移有一定相關性,對臨床綜閤治療和判斷預後可能具有重要指導意義.
목적 통과검측원발성간암환자혈청중혈관내피생장인자(VEGF)화종류배사인자(TNF-α)적수평변화,탐토기재간암발생발전급전이중적림상의의.방법 채용ELISA법검측87례학진위원발성간암환자혈청VEGF화TNF-α수평,동시측정10례건강인혈청작위대조.결과 원발성간암환자혈청VEGF화TNF-α수평명현증고[(586.38±148.21)ng/L,(178.45±32.15)ng/L],여대조조[(217.62+94.14)ng/L,(19.35±4.27)ng/L]상비차이균유통계학의의(P＜0.01);차외,합병간염병독감염혹발생전이적간암환자VEGF화TNF-α수평균명현고우비간염간암화미전이조간암환자,차이유통계학의의(P＜0.01).결론 원발성간암환자혈청VEGF화TNF-α수평여간암병변발전급전이유일정상관성,대림상종합치료화판단예후가능구유중요지도의의.
Objective To investigate vascular endothelial growth factor(VEGF) and TNF-α levels in the serum of patients with primary hepatocellur carcinoma(HCC),and to evaluate their relevance with the development and metastasis of HCC.Methods VEGF and TNF-α levels in serum were examined by enzyme linked immunosorbent assay(ELISA) technology in 87 patients with HCC and 10 healthy individuals.Results Serum VEGF and TNF-α,levels in HCC patients were significantly higher than that in the contorl group.In addition,HCC patients infected with hepatitis virus(including HBV and HCV) showed a remarkable elevation in serum VEGF and TNF-α levels.The VEGF and TNF-α levels in HCC with metastasis were also higher than those without metastasis.Conclusion The serum VEGF and TNF-α levels in HCC patients might serve as the pivotal biological indices that could reflect HCC progressien and metastasis.
