中华放射医学与防护杂志
中華放射醫學與防護雜誌
중화방사의학여방호잡지
Chinese Journal of Radiological Medicine and Protection
2008年
3期
262-264
,共3页
夏广荣%刘桂梅%靳国华%李雪冰
夏廣榮%劉桂梅%靳國華%李雪冰
하엄영%류계매%근국화%리설빙
肿瘤%骨转移%止痛%放射疗法%治疗结果
腫瘤%骨轉移%止痛%放射療法%治療結果
종류%골전이%지통%방사요법%치료결과
Neoplasms%Bone metastases%Pain relief%Radiotherapy%Outcome
目的 分析骨转移癌放疗止痛疗效.方法 将189例原发灶为肺癌的骨转移癌计221个病灶的放疗结果进行回顾性分析.放疗方案分为2种剂量分割组:(1)常规分割组:2 Gy/次,5次/周,总剂量30～50 Gy,共163个病灶;(2)中～低分割组:3～5 Gy/次,2～3次,周,总剂量20～40 Gv,共58个病灶.对不同病理类型和原发灶控制情况下的放疗结果进行分层分析.结果 常规分割、中.低分割组有效率分别为90.7%和87.9%(x2=1.229,P>0.05),总有效率为90.0%.小细胞癌、非小细胞肺癌的有效率分别为92.4%和89.0%(x2=0.668,P>0.05).原发灶控制与未控制的有效率为88.4%和91.7%(x2=0.787,P>0.05).结论 放疗是一种有效止痛方式,可作为骨转移癌首选治疗方法.不同分割剂量放疗对骨转移疼痛的缓解程度无影响,放疗疗效与原发灶病理类型及原发灶控制与否关系不明显.
目的 分析骨轉移癌放療止痛療效.方法 將189例原髮竈為肺癌的骨轉移癌計221箇病竈的放療結果進行迴顧性分析.放療方案分為2種劑量分割組:(1)常規分割組:2 Gy/次,5次/週,總劑量30～50 Gy,共163箇病竈;(2)中～低分割組:3～5 Gy/次,2～3次,週,總劑量20～40 Gv,共58箇病竈.對不同病理類型和原髮竈控製情況下的放療結果進行分層分析.結果 常規分割、中.低分割組有效率分彆為90.7%和87.9%(x2=1.229,P>0.05),總有效率為90.0%.小細胞癌、非小細胞肺癌的有效率分彆為92.4%和89.0%(x2=0.668,P>0.05).原髮竈控製與未控製的有效率為88.4%和91.7%(x2=0.787,P>0.05).結論 放療是一種有效止痛方式,可作為骨轉移癌首選治療方法.不同分割劑量放療對骨轉移疼痛的緩解程度無影響,放療療效與原髮竈病理類型及原髮竈控製與否關繫不明顯.
목적 분석골전이암방료지통료효.방법 장189례원발조위폐암적골전이암계221개병조적방료결과진행회고성분석.방료방안분위2충제량분할조:(1)상규분할조:2 Gy/차,5차/주,총제량30～50 Gy,공163개병조;(2)중～저분할조:3～5 Gy/차,2～3차,주,총제량20～40 Gv,공58개병조.대불동병리류형화원발조공제정황하적방료결과진행분층분석.결과 상규분할、중.저분할조유효솔분별위90.7%화87.9%(x2=1.229,P>0.05),총유효솔위90.0%.소세포암、비소세포폐암적유효솔분별위92.4%화89.0%(x2=0.668,P>0.05).원발조공제여미공제적유효솔위88.4%화91.7%(x2=0.787,P>0.05).결론 방료시일충유효지통방식,가작위골전이암수선치료방법.불동분할제량방료대골전이동통적완해정도무영향,방료료효여원발조병리류형급원발조공제여부관계불명현.
Objective To evaluate the efficacy of radiotherapy on bone metastases of lung cancer. Methods 189 patients with painful bone metastasis were investigated retrospectively from January 2000 tO November 2006.There were two radiotherapy groups in this study.Conventional fractionation group was 2 Gy/ fraction/day,5 days/week to 30-50 Gy,including 163 tumors.The middle fractionation and hypofraction group was 3-5 Gy/fraction/day,2-3 days/week to 20-40 Gy,including 58 tumors.Subgroup analysis were used for radiotherapy responses according to pathologic type and primary tumor control status.Results The response rates were 90.7%and 87.9%(x2=1.229,P>0.05),respectively,in conventional fractionation,middle fractionation and hypofractionation groups while the overall response rate was 90.O%.In subgroup analysis.the response rates were 92.4%and 89.0%(x2=0.668,P>0.05),respectively in small cell lung cancer and non-small cell lung cancer.The response rates were 88.4%and 91.7%(x2=0.787,P>0.05)in controlled primary tumor and not controlled primary tumor subgroups.Conclusions Radiotherapy is effective and could be the first option that can relieve bone pain in bone metastasis of lung cancer.However.different dose- fraetionation,different pathologic type and primary tumor control status have no significant impact on effect of radiotherapy.
