中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2008年
7期
473-475
,共3页
陈书悦%宋为民%杜晓航%韩长元
陳書悅%宋為民%杜曉航%韓長元
진서열%송위민%두효항%한장원
皮炎%糖皮质激素类%皮肤屏障功能%皮肤含水量%经皮水分丢失
皮炎%糖皮質激素類%皮膚屏障功能%皮膚含水量%經皮水分丟失
피염%당피질격소류%피부병장공능%피부함수량%경피수분주실
Dermatitis%Glucocorticoids%Skin barrier function%Skin hydration%Transepidermal water loss
目的 分析面部糖皮质激素依赖性皮炎患者的皮肤屏障功能.方法 将面部分为额部、鼻尖、下颌、双面颊、双侧口角的皮损区及左耳后无皮损区共8个点,分别测量95例面部糖皮质激素依赖性皮炎患者及25例健康对照者的经皮水分丢失(TEWL)和皮肤含水量.结果 与健康组相比,面部糖皮质激素依赖性皮炎组下颌、双侧口角、双面颊TEWL值均显著升高(t值分别为4.90,2.60,2.57,2.54,3.77,P＜0.01);双侧口角、右面颊及额部的皮肤含水量均显著降低(t值分别为3.27,3.81,2.02,2.78,P＜0.05).在8个测量点中,面部糖皮质激素依赖性皮炎组与健康组TEWL值均为下颌及双侧口角＞双面颊及额部＞耳后无皮损区;皮肤含水量降低均为下颌及双侧口角＞双面颊及额部＞耳后无皮损区.结论 面部糖皮质激素依赖性皮炎患者下颌、双侧口角、双面颊区域皮肤屏障功能受损,口周区域TEWL值较高,而面颊皮肤水分含量较少.
目的 分析麵部糖皮質激素依賴性皮炎患者的皮膚屏障功能.方法 將麵部分為額部、鼻尖、下頜、雙麵頰、雙側口角的皮損區及左耳後無皮損區共8箇點,分彆測量95例麵部糖皮質激素依賴性皮炎患者及25例健康對照者的經皮水分丟失(TEWL)和皮膚含水量.結果 與健康組相比,麵部糖皮質激素依賴性皮炎組下頜、雙側口角、雙麵頰TEWL值均顯著升高(t值分彆為4.90,2.60,2.57,2.54,3.77,P＜0.01);雙側口角、右麵頰及額部的皮膚含水量均顯著降低(t值分彆為3.27,3.81,2.02,2.78,P＜0.05).在8箇測量點中,麵部糖皮質激素依賴性皮炎組與健康組TEWL值均為下頜及雙側口角＞雙麵頰及額部＞耳後無皮損區;皮膚含水量降低均為下頜及雙側口角＞雙麵頰及額部＞耳後無皮損區.結論 麵部糖皮質激素依賴性皮炎患者下頜、雙側口角、雙麵頰區域皮膚屏障功能受損,口週區域TEWL值較高,而麵頰皮膚水分含量較少.
목적 분석면부당피질격소의뢰성피염환자적피부병장공능.방법 장면부분위액부、비첨、하합、쌍면협、쌍측구각적피손구급좌이후무피손구공8개점,분별측량95례면부당피질격소의뢰성피염환자급25례건강대조자적경피수분주실(TEWL)화피부함수량.결과 여건강조상비,면부당피질격소의뢰성피염조하합、쌍측구각、쌍면협TEWL치균현저승고(t치분별위4.90,2.60,2.57,2.54,3.77,P＜0.01);쌍측구각、우면협급액부적피부함수량균현저강저(t치분별위3.27,3.81,2.02,2.78,P＜0.05).재8개측량점중,면부당피질격소의뢰성피염조여건강조TEWL치균위하합급쌍측구각＞쌍면협급액부＞이후무피손구;피부함수량강저균위하합급쌍측구각＞쌍면협급액부＞이후무피손구.결론 면부당피질격소의뢰성피염환자하합、쌍측구각、쌍면협구역피부병장공능수손,구주구역TEWL치교고,이면협피부수분함량교소.
Objective To analyze the skin barrier function in patients with facial steroid dermatitis.Methods Ninety-five patients with facial steroid dermatitis were enrolled into this study along with 25 healthy volunteers as controls.Transepidermal water loss(TEWL)and skin hydration were measured in 8 facial regions.including lesional skin in forehead,nasal tip,submaxilla,both cheeks and angulus oris,and non-lesional skin in the left posteior ear.Results Compared with the healthy group,the patients with steroid dermatitis had a significant higher value of TEWL on lower mandible,both angulus oris and cheeks(t:4.90,2.60,2.57,2.54,3.77,respectively,P＜0.01),while a significant lower level of skin hydration was noted on both angulus otis,right cheek and forehead(t=3.27,3.81,2.02,2.78,respectively,P＜0.05).Among the 8 test sites in both patients and controls,TEWL value decreased in the following order:submaxilla and both angulus oris＞both cheeks and forehead＞non lesional skin on the posteroir ear,and the decrease in skin water content was highest in submaxilla and both angnlus oris,followed by cheeks and forehead,and finally by left posterior ear.Conclusions In patients with facial steroid dermatitis,skin barrier function is disturbed on submaxilla,both angnlus oris and cheeks,and TEWL value is found to be higher in perioral area,while cheeks have a lower level of skin hydration.
