中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
12期
48-49
,共2页
缺氧缺血%脑%神经生长因子%婴儿,新生
缺氧缺血%腦%神經生長因子%嬰兒,新生
결양결혈%뇌%신경생장인자%영인,신생
Hypoxic-ischemic%Brain%Nerve growth factor%Infant%Newborn
目的 观察神经生长因子(NGF)早期治疗新生儿中重度缺氧缺血性脑病(HIE)的疗效.方法 中重度HIE新生儿86例随机分为2组:对照组42例,NGF干预组44例,2组患儿均予常规治疗.干预组在常规治疗的基础上早期(生后6 h内)应用NGF静脉滴注治疗,1次/d,10～14 d为1个疗程.治疗前、治疗1个疗程和28 d检查头颅CT、行新生儿行为神经评分(NBNA),3个月和6个月采用首都儿科研究所儿心量表(CDCC)评定智力(MDI)/运动(PDI)发育指数.结果 NGF干预组头颅CT影像学脑结构的恢复及NBNA评分均明显优于对照组(P＜0.05),MDI、PDI等各项指标与对照组比较有明显改善(P＜0.01).结论 早期应用NGF治疗中重度新生儿HIE疗效明显.
目的 觀察神經生長因子(NGF)早期治療新生兒中重度缺氧缺血性腦病(HIE)的療效.方法 中重度HIE新生兒86例隨機分為2組:對照組42例,NGF榦預組44例,2組患兒均予常規治療.榦預組在常規治療的基礎上早期(生後6 h內)應用NGF靜脈滴註治療,1次/d,10～14 d為1箇療程.治療前、治療1箇療程和28 d檢查頭顱CT、行新生兒行為神經評分(NBNA),3箇月和6箇月採用首都兒科研究所兒心量錶(CDCC)評定智力(MDI)/運動(PDI)髮育指數.結果 NGF榦預組頭顱CT影像學腦結構的恢複及NBNA評分均明顯優于對照組(P＜0.05),MDI、PDI等各項指標與對照組比較有明顯改善(P＜0.01).結論 早期應用NGF治療中重度新生兒HIE療效明顯.
목적 관찰신경생장인자(NGF)조기치료신생인중중도결양결혈성뇌병(HIE)적료효.방법 중중도HIE신생인86례수궤분위2조:대조조42례,NGF간예조44례,2조환인균여상규치료.간예조재상규치료적기출상조기(생후6 h내)응용NGF정맥적주치료,1차/d,10～14 d위1개료정.치료전、치료1개료정화28 d검사두로CT、행신생인행위신경평분(NBNA),3개월화6개월채용수도인과연구소인심량표(CDCC)평정지력(MDI)/운동(PDI)발육지수.결과 NGF간예조두로CT영상학뇌결구적회복급NBNA평분균명현우우대조조(P＜0.05),MDI、PDI등각항지표여대조조비교유명현개선(P＜0.01).결론 조기응용NGF치료중중도신생인HIE료효명현.
Objective To observe the curative efects of never growth factor (NGF)on neonates with moderate and severe hypoxic-ischemic encephalopathy (HIE). Methods Eighty-six neonates with HIE were randomly divided into NGF treatment group and control group. The control group (42 cases)were received routine treatment (including cerebrolysin and citicoline) ;the treatment group (44 cages)were given NGF on the basis of routine treatment as early as possible (within 6 hours after birth). Brain CT, neonatal behavioral neuro-logical assessment(NBNA) and children' s development center of China(CDCC) at 3 and 6 months after birth were proformed in both groups. Results Brain CT, NBNA and CDCC markers in treatment group were better than those in control group (P＜ 0. 05). There were great diferences between two groups (P＜ 0. 01). Conclusion Using NGF on the basis of the routine treatment as early as possible after resuscitation can reduce markely the severity of asphyxia induced brain damage in neonates. It is very effective using NGF in treating HIE in neonates.
