中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
9期
1056-1057
,共2页
心动过速,室上性,阵发性%普罗帕酮%胺碘酮%治疗效果%安全性
心動過速,室上性,陣髮性%普囉帕酮%胺碘酮%治療效果%安全性
심동과속,실상성,진발성%보라파동%알전동%치료효과%안전성
Tachycardia,supraventricular,paroxysmal%Propafenone%Amiodarone%Treatment effect%Safety
目的 比较普罗帕酮和胺碘酮静脉用于急诊转复阵发性室上性心动过速的疗效及不良反应.方法 将急诊阵发性室上性心动过速患者86例完全随机分成普罗帕酮组(44例)和胺碘酮组(42例),普罗帕酮组给予普罗帕酮70 mg静脉注射(5 min注完),若无效,20min后重复1次;胺碘酮组给予胺碘酮5～7 mg/kg加入100 ml 5%葡萄糖或0.9%氯化钠注射液中静脉滴注,30 min滴完,继之以1 mg/min的速度持续静脉滴注.观察2组的治疗效果和不良反应发生情况.结果 普罗帕酮组和胺碘酮组转复有效率分别为93.2%(41/44)和88.1%(37/42)(P＞0.05);平均转复时间普罗帕酮组[(12.4±7.8)min]明显短于胺碘酮组[(30.7±10.3)min](P＜0.01);不良反应发生率普罗帕酮组为[29.5%(13/44)]明显高于胺碘酮组[11.9%(5/42)](P＜0.05).结论 普罗帕酮和胺碘酮用于急诊转复阵发性室上性心动过速,疗效基本相同,但普罗帕酮起效快,更适用于无器质性心脏疾患者,胺碘酮用于有器质性心脏疾患者较普罗帕酮相对安全.
目的 比較普囉帕酮和胺碘酮靜脈用于急診轉複陣髮性室上性心動過速的療效及不良反應.方法 將急診陣髮性室上性心動過速患者86例完全隨機分成普囉帕酮組(44例)和胺碘酮組(42例),普囉帕酮組給予普囉帕酮70 mg靜脈註射(5 min註完),若無效,20min後重複1次;胺碘酮組給予胺碘酮5～7 mg/kg加入100 ml 5%葡萄糖或0.9%氯化鈉註射液中靜脈滴註,30 min滴完,繼之以1 mg/min的速度持續靜脈滴註.觀察2組的治療效果和不良反應髮生情況.結果 普囉帕酮組和胺碘酮組轉複有效率分彆為93.2%(41/44)和88.1%(37/42)(P＞0.05);平均轉複時間普囉帕酮組[(12.4±7.8)min]明顯短于胺碘酮組[(30.7±10.3)min](P＜0.01);不良反應髮生率普囉帕酮組為[29.5%(13/44)]明顯高于胺碘酮組[11.9%(5/42)](P＜0.05).結論 普囉帕酮和胺碘酮用于急診轉複陣髮性室上性心動過速,療效基本相同,但普囉帕酮起效快,更適用于無器質性心髒疾患者,胺碘酮用于有器質性心髒疾患者較普囉帕酮相對安全.
목적 비교보라파동화알전동정맥용우급진전복진발성실상성심동과속적료효급불량반응.방법 장급진진발성실상성심동과속환자86례완전수궤분성보라파동조(44례)화알전동조(42례),보라파동조급여보라파동70 mg정맥주사(5 min주완),약무효,20min후중복1차;알전동조급여알전동5～7 mg/kg가입100 ml 5%포도당혹0.9%록화납주사액중정맥적주,30 min적완,계지이1 mg/min적속도지속정맥적주.관찰2조적치료효과화불량반응발생정황.결과 보라파동조화알전동조전복유효솔분별위93.2%(41/44)화88.1%(37/42)(P＞0.05);평균전복시간보라파동조[(12.4±7.8)min]명현단우알전동조[(30.7±10.3)min](P＜0.01);불량반응발생솔보라파동조위[29.5%(13/44)]명현고우알전동조[11.9%(5/42)](P＜0.05).결론 보라파동화알전동용우급진전복진발성실상성심동과속,료효기본상동,단보라파동기효쾌,경괄용우무기질성심장질환자,알전동용우유기질성심장질환자교보라파동상대안전.
Objective To evaluate the efficacy and safety of propafenone and amiodarone in the treatment of paroxysmal supraventricular tachycardia(PSVT). Methods Total 86 cases of PSVT were randomly divided into propafenone group and amiodarone group. Propafenone group had intravenously injected 70 mg propafenone. The intravenous injections lasted 5 minutes. Amiodarone group were intravenously infused amiodarone(5-7 mg/kg) (the intravenous infusion lasted 30 minutes). Results The termination rate of PSVT was 93.2% in propafenone group and 88.1% in amiodarone group respectively. Cardioversion time showed as follows: propafenone group(12.4 ±7.8 min) was significantly shorter than amiodarone group (30.7 ± 10.3) min (P ＜ 0.01). Side reaction showed that propafenone group(29.5%) was significantly higher than amiodarone group (11.9%) (P ＜ 0.05). Conclusions The effective cardioversion rates of propafenone and amiodarone in treating PSVT are high in emergency department.Propafenone shows faster effect and higher side effects but better outcome for patients without serious organic heart diseases than Amiodarone which is better for patients with serious organic heart diseases.
