CAJ | 학술논문

幽门螺杆菌(Helicobacter pylori,Hp)感染与胃肠道疾病中的慢性胃炎、消化性溃疡、胃癌等疾病的发生和发展密切相关.但是不同的人在Hp感染后临床表现差异很大,有的患者表现为长期无症状携带者,有的则在一段时间后发展为胃炎或胃癌.感染Hp后患者临床表现间的差异除了与其本身对疾病易感性有关外,细胞因子在Hp感染过程中发挥着重要作用.近年来有关细胞因子基因多态性与Hp及其继发性疾病的研究较多,本文对近年来有关细胞因子基因多态性与Hp及其继发性疾病的研究做一综述.
유문라간균(Helicobacter pylori,Hp)감염여위장도질병중적만성위염、소화성궤양、위암등질병적발생화발전밀절상관.단시불동적인재Hp감염후림상표현차이흔대,유적환자표현위장기무증상휴대자,유적칙재일단시간후발전위위염혹위암.감염Hp후환자림상표현간적차이제료여기본신대질병역감성유관외,세포인자재Hp감염과정중발휘착중요작용.근년래유관세포인자기인다태성여Hp급기계발성질병적연구교다,본문대근년래유관세포인자기인다태성여Hp급기계발성질병적연구주일종술.
Helicobacter pylori (Hp) infection plays an important role in the development of gastritis,gastric ulcer,duodenal ulcer and gastric cancer.But the clinical manifestations of different individuals infected by Hp vary widely,some are long-term asymptomatic carriers,others develop gastritis or gastric cancer.The cell factors are important in the process of Hp infection.Nowadays,the relations between cytokines gene polymorphism and Hp infection are studied and reported.This paper reviews the recent studies of cytokine gene polymorphisms and Hp and its secondary diseases.