国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2008年
4期
307-310
,共4页
免疫耐受%T细胞%调节性T细胞%阴性选择%阳性选择
免疫耐受%T細胞%調節性T細胞%陰性選擇%暘性選擇
면역내수%T세포%조절성T세포%음성선택%양성선택
Immune tolerance%T-cell%Regulatory T-cell%Negative selection%Positive selection
由于T细胞抗原受体(TCR)形成中的随机重排的特性,所以其不但产生对非己的外来抗原的,也产生对自己的自身成分的TCR.在胸腺中T细胞成熟过程要经历阳性选择,还要接受一系列阴性选择,包括克隆清除,克隆编辑,克隆无能或忽视,以达到维持自身免疫耐受.为确保进入外周的自身反应性T细胞维持耐受,具有调节功能的T细胞亚群发挥重要作用,如:CD25+CD4+调节性T细胞(Tr),CD8aa+IEL和Val4iNK-T细胞等,一些细胞因子如IL-10和TGF-β等也参与调节性T细胞的机制.
由于T細胞抗原受體(TCR)形成中的隨機重排的特性,所以其不但產生對非己的外來抗原的,也產生對自己的自身成分的TCR.在胸腺中T細胞成熟過程要經歷暘性選擇,還要接受一繫列陰性選擇,包括剋隆清除,剋隆編輯,剋隆無能或忽視,以達到維持自身免疫耐受.為確保進入外週的自身反應性T細胞維持耐受,具有調節功能的T細胞亞群髮揮重要作用,如:CD25+CD4+調節性T細胞(Tr),CD8aa+IEL和Val4iNK-T細胞等,一些細胞因子如IL-10和TGF-β等也參與調節性T細胞的機製.
유우T세포항원수체(TCR)형성중적수궤중배적특성,소이기불단산생대비기적외래항원적,야산생대자기적자신성분적TCR.재흉선중T세포성숙과정요경력양성선택,환요접수일계렬음성선택,포괄극륭청제,극륭편집,극륭무능혹홀시,이체도유지자신면역내수.위학보진입외주적자신반응성T세포유지내수,구유조절공능적T세포아군발휘중요작용,여:CD25+CD4+조절성T세포(Tr),CD8aa+IEL화Val4iNK-T세포등,일사세포인자여IL-10화TGF-β등야삼여조절성T세포적궤제.
During the process of antigen-specific T-cell differentiation in the thymus,a population of T-cell receptors,have more or less the ability responsible not only to foreign pathogens,but also to self peptide;So at the first level,thymic-regulated central tolerance removes developing thymocytes that strongly recognize self protein.It includes positive selection and negative selection.Negative.selection is composed of clonal deletion,clonal edition,cbnal anergy or ignorance.In the periphery.there are many lymphocytes and cyto-kines which have the function of regulation,known as CD25+ CD+ T regulatory cells,CD8aa+ IEL(intraep-ithelial lymphocytes)and invariant Val4 Natural Killer T cells,IL-10 and TGF-β,which contribute to the maintain of the peripheral tolerance.
