中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2008年
7期
1139-1140
,共2页
肝硬化%CA-19-9抗原%化学发光
肝硬化%CA-19-9抗原%化學髮光
간경화%CA-19-9항원%화학발광
Liver cirrhosis%CA- 19-9 antigen%Chemiluminescence
目的 动态观察肝硬化患者血清糖链抗原19-9(CA19-9)水平变化,建立判断预后的临界值.方法 肝硬化组:乙型肝炎肝硬化患者61例,根据Child-Pugh肝功能积分法分三级,A级27例,B级20例,C级14例;健康对照组35例.采用电化学发光法测定血清CA19-9的含量,同时作肝功能常规检测.结果 肝硬化组血清CA19-9水平比对照组显著升高(P<0.005),血清CA19-9水平变化与Child-Pugh肝功能积分、总胆红素(TBiL)、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)呈正相关,治疗后明显下降,特别是Child-Pugh A级和B级,与治疗前比较差异有统计学意义(P<0.05),有效率分别为67%和55%.经统计学处理建立判断肝硬化预后平均血清CA19-9水平的临界值为≥(98.4±10.3)KU/L.结论 肝硬化患者血清中CA19-9水平有不同程度升高,其水平≥(98.4±10.3)KU/L治疗效果及预后较差,可作为肝硬化患者肝功能损害程度及预后判断的指标.
目的 動態觀察肝硬化患者血清糖鏈抗原19-9(CA19-9)水平變化,建立判斷預後的臨界值.方法 肝硬化組:乙型肝炎肝硬化患者61例,根據Child-Pugh肝功能積分法分三級,A級27例,B級20例,C級14例;健康對照組35例.採用電化學髮光法測定血清CA19-9的含量,同時作肝功能常規檢測.結果 肝硬化組血清CA19-9水平比對照組顯著升高(P<0.005),血清CA19-9水平變化與Child-Pugh肝功能積分、總膽紅素(TBiL)、丙氨痠氨基轉移酶(ALT)和天鼕氨痠氨基轉移酶(AST)呈正相關,治療後明顯下降,特彆是Child-Pugh A級和B級,與治療前比較差異有統計學意義(P<0.05),有效率分彆為67%和55%.經統計學處理建立判斷肝硬化預後平均血清CA19-9水平的臨界值為≥(98.4±10.3)KU/L.結論 肝硬化患者血清中CA19-9水平有不同程度升高,其水平≥(98.4±10.3)KU/L治療效果及預後較差,可作為肝硬化患者肝功能損害程度及預後判斷的指標.
목적 동태관찰간경화환자혈청당련항원19-9(CA19-9)수평변화,건립판단예후적림계치.방법 간경화조:을형간염간경화환자61례,근거Child-Pugh간공능적분법분삼급,A급27례,B급20례,C급14례;건강대조조35례.채용전화학발광법측정혈청CA19-9적함량,동시작간공능상규검측.결과 간경화조혈청CA19-9수평비대조조현저승고(P<0.005),혈청CA19-9수평변화여Child-Pugh간공능적분、총담홍소(TBiL)、병안산안기전이매(ALT)화천동안산안기전이매(AST)정정상관,치료후명현하강,특별시Child-Pugh A급화B급,여치료전비교차이유통계학의의(P<0.05),유효솔분별위67%화55%.경통계학처리건립판단간경화예후평균혈청CA19-9수평적림계치위≥(98.4±10.3)KU/L.결론 간경화환자혈청중CA19-9수평유불동정도승고,기수평≥(98.4±10.3)KU/L치료효과급예후교차,가작위간경화환자간공능손해정도급예후판단적지표.
Objective To explore the clinical meanings of serum CA19-9 levd in hepatocirrhosis patients. Methods 61 hepatitis B and hepatocirrhosis patients were as treatment group, and 35 normal were as control group. The content of serum CA19-9 was measured by dectrochemistry lighting and the liver function was determined too. According to Child-Pugh liver function integral method,the treatment group was divided into 27 cases of A grade,20 cases of B grade and 14 cases of C grade. Results The serum CA19-9 level in hepatocirrhosis patients was higher than that of normal group significantly(P< 0. 005 ). The serum CA19-9 level decreaed obviously through the treat- ment,thereinto A and B grade fell evidendy in the Child-Pugh liver function integral method( P < 0. 005). C grade was not significantly different(P<0.05 ). The serum CA19-9 levd was positivdy associated with TBiL, ALT and AST of liver function integral method. Conclusion The serum CA19-9 levd of hepatocirrhosis patients is improved in different degrees. And it can be a prognostic target and used to estimate the degree of damage of liver function of hepatocirrhosis patients.
