CAJ | 학술논문

目的观察子(癎)前期患者血浆前列环素12(PGh)水平与眼底视网膜血管病变程度的关系.方法采用放射免疫法检测38例子(癎)前期患者(研究组)和30例正常足月妊娠待产孕妇(对照组)产前、产后血浆PGI2水平,同时专人检查其眼底视网膜病变情况,分析2组孕妇产前、产后血浆PGI2水平的差异及其与视网膜血管改变之间的关系.结果研究组产前及产后血浆PGI2:水平均明显低于对照组[(133.3±111.6)ng/L比(238.4±102.2)ng/L,(146.1±54.0)ng/L比(245.9±95.4)ng/L,均P<0.01].研究组眼底视网膜病变分期与产前血浆PGI2水平呈负相关(r=-0.644,P<0.05).结论血浆PGI2水平与子(癎)前期的病情和眼底病变有密切关系,PGI2水平下降在妊娠期高血压病患者的视网膜病变发生发展过程中发挥重要作用.
목적 관찰자(간)전기환자혈장전렬배소12(PGh)수평여안저시망막혈관병변정도적관계.방법 채용방사면역법검측38례자(간)전기환자(연구조)화30례정상족월임신대산잉부(대조조)산전、산후혈장PGI2수평,동시전인검사기안저시망막병변정황,분석2조잉부산전、산후혈장PGI2수평적차이급기여시망막혈관개변지간적관계.결과 연구조산전급산후혈장PGI2:수평균명현저우대조조[(133.3±111.6)ng/L비(238.4±102.2)ng/L,(146.1±54.0)ng/L비(245.9±95.4)ng/L,균P<0.01].연구조안저시망막병변분기여산전혈장PGI2수평정부상관(r=-0.644,P<0.05).결론 혈장PGI2수평여자(간)전기적병정화안저병변유밀절관계,PGI2수평하강재임신기고혈압병환자적시망막병변발생발전과정중발휘중요작용.
Objective To analyze the relationship between the senun prostacyclin( PGI2 ) level and the vascular lesion degree of retina in pre-eclampsia patients. Methods Serum level of PGI2 was detected by radio-immu-no analysis method in 38 cases of pre-eclampsia before and after delivery, and then was compared with that in 30 cases of healthy late gestational women. Meanwhile, the vascular lesion of retina was checked in all 38 cases and the correlation between its degree and the serum PGI2 level (before and after delivery) was analyzed. Results In the pre-eclampsia groups, serum level of PGI2 either before or after delivery was lower than that in the healthy gestational women group( 133.3 ±111.6 ng/L vs 238.4 ± 102. 2 ng/L, 146.1 ± 54. 0 ng/L vs 245.9 ± 95. 4 ng/L, P < 0.01 for all). A significant negative relationship was detected between the serum levels of PGI2 before delivery and the vascular lesion degree of retina in pre-eclampsia patients(r=-0.631, P<0.05). Conclusions There is a close relationship between the serum levels of PGI2 and blood vessel lesion of retina in patients with pre-eclampsia. The decrease of serum PGI2 may play important role in occurring and deterioration of retina blood vessel lesions.