中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
6期
764-765
,共2页
阿托品%弱视%依从性
阿託品%弱視%依從性
아탁품%약시%의종성
Atropine%Amblyopia%Compliance
目的 探讨阿托品联合短时遮盖治疗单眼弱视的临床疗效.方法 将120例单眼弱视患儿完全随机分为遮盖组(62例)和阿托品组(58例).遮盖组患儿遮盖弱视眼每天不少于8h；阿托品组患儿优势眼每日滴1％阿托品眼膏1次,连续用药10 d,停药15 d,并每日遮盖优势眼3～4h.随访20～36个月,并比较2组的依从性、有效率.结果 遮盖组患儿依从性逐渐下降,18个月内有9例放弃治疗,1例失访；阿托品组无一例放弃治疗；阿托品组患儿依从性明显好于遮盖组(P＜0.05).治疗6、12、18个月时阿托品组有效率分别为72.4％ (42/58)、84.5％ (49/58)、87.9％ (51/58),均明显高于遮盖组[35.5％ (22/62)、45.2％(28/62)、51.6％ (32/62)],差异有统计学意义(均P＜0.01).结论 阿托品联合短时遮盖有利于提高单眼弱视患儿治疗依从性,提高治愈率.
目的 探討阿託品聯閤短時遮蓋治療單眼弱視的臨床療效.方法 將120例單眼弱視患兒完全隨機分為遮蓋組(62例)和阿託品組(58例).遮蓋組患兒遮蓋弱視眼每天不少于8h；阿託品組患兒優勢眼每日滴1％阿託品眼膏1次,連續用藥10 d,停藥15 d,併每日遮蓋優勢眼3～4h.隨訪20～36箇月,併比較2組的依從性、有效率.結果 遮蓋組患兒依從性逐漸下降,18箇月內有9例放棄治療,1例失訪；阿託品組無一例放棄治療；阿託品組患兒依從性明顯好于遮蓋組(P＜0.05).治療6、12、18箇月時阿託品組有效率分彆為72.4％ (42/58)、84.5％ (49/58)、87.9％ (51/58),均明顯高于遮蓋組[35.5％ (22/62)、45.2％(28/62)、51.6％ (32/62)],差異有統計學意義(均P＜0.01).結論 阿託品聯閤短時遮蓋有利于提高單眼弱視患兒治療依從性,提高治愈率.
목적 탐토아탁품연합단시차개치료단안약시적림상료효.방법 장120례단안약시환인완전수궤분위차개조(62례)화아탁품조(58례).차개조환인차개약시안매천불소우8h；아탁품조환인우세안매일적1％아탁품안고1차,련속용약10 d,정약15 d,병매일차개우세안3～4h.수방20～36개월,병비교2조적의종성、유효솔.결과 차개조환인의종성축점하강,18개월내유9례방기치료,1례실방；아탁품조무일례방기치료；아탁품조환인의종성명현호우차개조(P＜0.05).치료6、12、18개월시아탁품조유효솔분별위72.4％ (42/58)、84.5％ (49/58)、87.9％ (51/58),균명현고우차개조[35.5％ (22/62)、45.2％(28/62)、51.6％ (32/62)],차이유통계학의의(균P＜0.01).결론 아탁품연합단시차개유리우제고단안약시환인치료의종성,제고치유솔.
Objective To evaluate the therapeutic effect of atropine combined with short-time occlusion for treatment of monocular amblyopia.Methods All 120 patients with monocular amblyopia were randomly divided into occlusion group(62 cases) and atropine group(58 cases).The children in occlusion group were covered superior eye more than 8 hours a day,while the children in atropine group were covered superior eye for 3 to 4 hours a day,at the same time the superior eye was dropped atropine eye ointment once a day for 10 days a month.All cases were observed for 20 to 36 months,and compliance of patients and effective rate were analyzed and compared.Results Compliance gradually decreased in occlusion group,and there were 10 cases withdrew from treatment.In atroping group without a case abandoning treatment.The compliance in atroping group was better than that in occlusion group ( P ＜0.05).For 6 months,12 months and 18 months of treatment the effective rates in atroping group were 72.4％(42/58),84.5％ ( 49/58 ),87.9％ ( 51/58 ) respectively,which were significantly higher than those in occlusion group[35.5％(22/62),45.2％(28/62),51.6％(32/62)] (all P＜0.01).Conclusions Atropinepenalization and patching are both effective methods in treating amblyopia.Atropine combined with short-time occlusion for treatment of monocular amblyopia can improve the treatment compliance and increase the cure rate.
