国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2011年
9期
783-785
,共3页
林峰%赵君%常万生%李杰云
林峰%趙君%常萬生%李傑雲
림봉%조군%상만생%리걸운
脑梗死%银杏达莫注射液%复方丹参注射液
腦梗死%銀杏達莫註射液%複方丹參註射液
뇌경사%은행체막주사액%복방단삼주사액
Cerebral infaruction%Ginkgo bilobate extract injection%Edaravone injection
目的 观察银杏达莫注射液对脑梗死患者血液流变学、血脂及血清C反应蛋白的影响。方法 将62例脑梗死患者按照随机数字表法分为两组各31例，均给予常规治疗。对照组在常规治疗基础上给予复方丹参注射液20 ml加入5％葡萄糖注射液250 ml，静脉滴注，1次/d，连用14 d。治疗组在常规治疗基础上给予银杏达莫注射液20 ml加入5％葡萄糖注射液250 ml，静脉滴注，1次/d，连用14 d。观察治疗前后患者的临床症状、血液流变学指标、血脂水平及血清C-反应蛋白水平，并进行疗效评定。结果 治疗组血液流变学指标以全血黏度降低最为明显(1.57±0.28) mpa·s(P＜0.01)。全血还原黏度( 13.95±2.07) mpa·s、红细胞聚集指数(1.37±0.12)、红细胞压积(42.36±8.16)％亦下降，与对照组比较差异均有统计学意义(P＜0.05)。治疗组血清TG( 1.23±0.12) mmol/L、TC (4.29±1.17) mmol/L、LDL-C (2.31±0.39) mmol/L较对照组明显降低(P＜0.01或P＜ 0.05)；血清HDL-C( 1.78±0.76) mmol/L明显升高(JP＜0.01)。治疗组血清C-反应蛋白(10.48±3.82) mg/L水平较对照组明显降低(P＜0.05)。治疗组总有效率为87.1％、对照组为67.7％，两组总有效率比较，差异有统计学意义(x2=3.553，P=0.041 ＜0.05)。结论 银杏达莫注射液可通过调整血液黏度、血脂水平改善脑梗死患者的症状。
目的 觀察銀杏達莫註射液對腦梗死患者血液流變學、血脂及血清C反應蛋白的影響。方法 將62例腦梗死患者按照隨機數字錶法分為兩組各31例，均給予常規治療。對照組在常規治療基礎上給予複方丹參註射液20 ml加入5％葡萄糖註射液250 ml，靜脈滴註，1次/d，連用14 d。治療組在常規治療基礎上給予銀杏達莫註射液20 ml加入5％葡萄糖註射液250 ml，靜脈滴註，1次/d，連用14 d。觀察治療前後患者的臨床癥狀、血液流變學指標、血脂水平及血清C-反應蛋白水平，併進行療效評定。結果 治療組血液流變學指標以全血黏度降低最為明顯(1.57±0.28) mpa·s(P＜0.01)。全血還原黏度( 13.95±2.07) mpa·s、紅細胞聚集指數(1.37±0.12)、紅細胞壓積(42.36±8.16)％亦下降，與對照組比較差異均有統計學意義(P＜0.05)。治療組血清TG( 1.23±0.12) mmol/L、TC (4.29±1.17) mmol/L、LDL-C (2.31±0.39) mmol/L較對照組明顯降低(P＜0.01或P＜ 0.05)；血清HDL-C( 1.78±0.76) mmol/L明顯升高(JP＜0.01)。治療組血清C-反應蛋白(10.48±3.82) mg/L水平較對照組明顯降低(P＜0.05)。治療組總有效率為87.1％、對照組為67.7％，兩組總有效率比較，差異有統計學意義(x2=3.553，P=0.041 ＜0.05)。結論 銀杏達莫註射液可通過調整血液黏度、血脂水平改善腦梗死患者的癥狀。
목적 관찰은행체막주사액대뇌경사환자혈액류변학、혈지급혈청C반응단백적영향。방법 장62례뇌경사환자안조수궤수자표법분위량조각31례，균급여상규치료。대조조재상규치료기출상급여복방단삼주사액20 ml가입5％포도당주사액250 ml，정맥적주，1차/d，련용14 d。치료조재상규치료기출상급여은행체막주사액20 ml가입5％포도당주사액250 ml，정맥적주，1차/d，련용14 d。관찰치료전후환자적림상증상、혈액류변학지표、혈지수평급혈청C-반응단백수평，병진행료효평정。결과 치료조혈액류변학지표이전혈점도강저최위명현(1.57±0.28) mpa·s(P＜0.01)。전혈환원점도( 13.95±2.07) mpa·s、홍세포취집지수(1.37±0.12)、홍세포압적(42.36±8.16)％역하강，여대조조비교차이균유통계학의의(P＜0.05)。치료조혈청TG( 1.23±0.12) mmol/L、TC (4.29±1.17) mmol/L、LDL-C (2.31±0.39) mmol/L교대조조명현강저(P＜0.01혹P＜ 0.05)；혈청HDL-C( 1.78±0.76) mmol/L명현승고(JP＜0.01)。치료조혈청C-반응단백(10.48±3.82) mg/L수평교대조조명현강저(P＜0.05)。치료조총유효솔위87.1％、대조조위67.7％，량조총유효솔비교，차이유통계학의의(x2=3.553，P=0.041 ＜0.05)。결론 은행체막주사액가통과조정혈액점도、혈지수평개선뇌경사환자적증상。
Objective To observe effects of ginkgo bilobate extract injection on the hemorheology,blood lipid and c-reactive protein in serum of patients with cerebral infarction. Methods 62 cases patients with cerebral infarction were randomly divided into two groups by means of random number table. Two groups were both given routine treatment. The control group was treated with 20ml compound salvia injection, which was added to 250 ml normal saline, once a day, continuous therapy for 14 days, and the treatment group was treated with 20ml ginkgo bilobate extract injection, which was added to 250 ml normal saline, once a day, continuous therapy for 14 days. The clinical symptoms were observed, hemorheology related index, level of blood lipid and c-reactive protein were detected before and after the treatment. Results Compared with the control group,hemorheology related index decreased significantly in the treatment group, especially whole blood viscosity ( 1.57±0.28) mpa ·s (P＜0.01). Blood reduced viscosity (13.95 ± 2.07) mpa ·s, erythrocyte aggregation index (1.37±0.12) , hematocrit (42.36±8.16) were also decreased significantly (P＜0.05) .Triglyceride (TG)(1.23±0.12) mmol/L、 cholesterol (TC) (4.29±1.17) mmtmol/L、 low density lipoprotein cholesterol (LDIL-C)(2.31± 0.39) mmol/L and c-reactive protein ( 10.48 ±- 3.82) mg/L in serum in the treatment group were lower than those of the control group (P＜0.01 orP＜0.05) , high density lipoprotein cholesterol (HDL-C) ( 1.78±0.76) mmol/L in serum was higher than that of the control group (P＜0.01) .The total effective rate of the treatment group and the control group was 87.1％ and 67.7％ respectively, there was a significant difference (x2=3.553, P＜0.05). Conclusion The ginkgo bilobate extract injection can protect cerebral infarction from injury,which may be related with its action on regulating the blood viscosity and level of blood lipid.
