CAJ | 학술논문

白细胞介素(IL)-27是一种新的IL-6/IL-12家族成员,由p28亚基和EB病毒诱导基因3(EBI3)亚基组成异源二聚体复合物,其受体由WSX-1和gp130组成,在炎症反应的不同阶段或不同刺激条件下,具有促进炎症和抑制炎症的双重性质.研究已表明,IL-27可通过激活Janus激酶/信号转导和转录激活因子(JAK/STAT)信号转导通路,调节Th1、Th17及相关细胞因子的分泌发挥相应的生物学作用.IL-27还可通过增强细胞毒性T细胞活性和抗血管生成作用参与机体抗肿瘤作用.
백세포개소(IL)-27시일충신적IL-6/IL-12가족성원,유p28아기화EB병독유도기인3(EBI3)아기조성이원이취체복합물,기수체유WSX-1화gp130조성,재염증반응적불동계단혹불동자격조건하,구유촉진염증화억제염증적쌍중성질.연구이표명,IL-27가통과격활Janus격매/신호전도화전록격활인자(JAK/STAT)신호전도통로,조절Th1、Th17급상관세포인자적분비발휘상응적생물학작용.IL-27환가통과증강세포독성T세포활성화항혈관생성작용삼여궤체항종류작용.
Interleukin (IL)-27 is a new member of the IL-6/IL-12 family composed of p28 subunit and Epstein-Barr virus induced gene 3 (EBI3) subunit. Its receptor is composed of WSX-1 and gp130. It has dual properties including pro-inflammatory and anti-inflammatory function at different conditions. Studies have shown that IL-27 exerts its biological activities through stimulating JAK1/STAT1, JAK1/STAT3 signal pathways and regulating the production of Th1, Th17 as well as their related-cytokines. Furthermore, IL-27 can exert the role of anti-tumor activity by enhancing the effect of cytotoxic T cells and anti-angiogenesis.