CAJ | 학술논문

目的观察阿托伐他汀对血脂正常的初诊2型糖尿病大血管病变患者超敏C反应蛋白(hs-CRP)的影响.方法 96例患者随机分为治疗组49例和对照组47例,两组患者均在饮食指导及生活方式干预基础上加用降糖治疗,治疗组加用阿托伐他汀10 mg每晚1次,共12周.对照组予安慰剂12周.均空腹采血查两组空腹血糖(FBG)、餐后2 h血糖(PPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、hs-CRP.结果治疗后治疗组hs-CRP水平显著低于对照组[(2.13±1.38)mg/L与(4.04±3.14)mg/L,P<0.05].结论阿托伐他汀能显著降低血脂正常的初诊2型糖尿病大血管病变患者ks-CRP水平,对预防动脉硬化的进展有良好作用.
목적 관찰아탁벌타정대혈지정상적초진2형당뇨병대혈관병변환자초민C반응단백(hs-CRP)적영향.방법 96례환자수궤분위치료조49례화대조조47례,량조환자균재음식지도급생활방식간예기출상가용강당치료,치료조가용아탁벌타정10 mg매만1차,공12주.대조조여안위제12주.균공복채혈사량조공복혈당(FBG)、찬후2 h혈당(PPG)、당화혈홍단백(HbA1c)、총담고순(TC)、감유삼지(TG)、저밀도지단백(LDL-C)、hs-CRP.결과 치료후치료조hs-CRP수평현저저우대조조[(2.13±1.38)mg/L여(4.04±3.14)mg/L,P<0.05].결론 아탁벌타정능현저강저혈지정상적초진2형당뇨병대혈관병변환자ks-CRP수평,대예방동맥경화적진전유량호작용.
Objective To observe influence of atorvastatin to high sensitive C-reactlve protein in the new on-set type 2 diabetes of normal blood lipid with macrovascular disease. Methods 96 cases with the new onset type 2 diabetes of normal blood lipid with macrovascu]ar disease were randomly divided into two groups,the treatment group contains 49 cases who were given atorvastatin 10rag for 12 weeks,the control group contains 47 cases who were given placebo for 12 weeks. Two groups were underwent the following test,fasting plasma glucose(FBG) ,post-OGTT 2 hour plasma glucose(PPG) ,glycosy-lated hemoglobin(HbAic) ,total triglyceride(TG) ,total cholesterol(TC) ,low density lipoprotein cholesterol(LDL-C) ,high sensitive C-reactive protein(hs-CRP). Results High sensitive C-reactive pro-tein(hs-CRP) in treatment group is significantly lower than control group[(2.13±1.38) mg/L and (4.04±3.14) mg/L,P < 0.05]. Conclusion Atorvastatin can significantly decease the level of high sensitive C-reactive protein (hs-CRP) to the new onset type 2 diabetes of normal blood lipid with macrovascular disease.