中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2012年
10期
852-855
,共4页
陈贤明%窦晓晴%梁永辉%张丽卫%罗碧强%邓意红
陳賢明%竇曉晴%樑永輝%張麗衛%囉碧彊%鄧意紅
진현명%두효청%량영휘%장려위%라벽강%산의홍
老年性聋%听觉皮质%磁共振波谱学
老年性聾%聽覺皮質%磁共振波譜學
노년성롱%은각피질%자공진파보학
Presbycusis%Auditory cortex%Magnetic resonance spectroscopy
目的 利用氢质子磁共振波谱(hydrogen magnetic resonance spectroscopy,1H-MRS)技术观察老年性聋患者听皮层的代谢变化.方法 选取10名健康青年志愿者(青年组)、10名听力正常老年人(老年组)及8例老年性聋患者(老年性聋组),分别行1 H-MRS检测其双侧颞横回N-乙酰天门冬氨酸( N-acetylaspartic acid,NAA)、肌酸(creatine,Cr)、胆碱(choline,Cho)、γ-氨基丁酸(γ-aminobutyric acid,GABA)及谷氨酸(glutamic acid,Glu)的峰下面积,计算其NAA/Cr、Cho/Cr、GABA/Cr、Glu/Cr的比值,比较三组受试者间的代谢差异.结果 与青年组比较,老年组和老年性聋组双侧听皮层NAA/Cr降低,而Cho/Cr升高,差异具有统计学意义(P值均＜0.05)；老年组GABA/Cr、Glu/Cr比值与青年组相比,差异无统计学意义(P值均＞0.05)；老年性聋组GABA/Cr降低,Glu/Cr升高,与青年组相比差异具有统计学意义(P值均＜0.05).与老年组相比,老年性聋组双侧听皮层NAA/Cr、GABA/Cr比值进一步降低,Cho/Cr、Glu/Cr比值进一步升高,差异具有统计学意义(P＜值均0.05).结论1H-MRS可以为人体活体听皮层代谢物浓度改变提供有价值的信息.老年性聋患者听皮层存在NAA、GABA代谢减少及Cho、Glu代谢升高的现象.
目的 利用氫質子磁共振波譜(hydrogen magnetic resonance spectroscopy,1H-MRS)技術觀察老年性聾患者聽皮層的代謝變化.方法 選取10名健康青年誌願者(青年組)、10名聽力正常老年人(老年組)及8例老年性聾患者(老年性聾組),分彆行1 H-MRS檢測其雙側顳橫迴N-乙酰天門鼕氨痠( N-acetylaspartic acid,NAA)、肌痠(creatine,Cr)、膽堿(choline,Cho)、γ-氨基丁痠(γ-aminobutyric acid,GABA)及穀氨痠(glutamic acid,Glu)的峰下麵積,計算其NAA/Cr、Cho/Cr、GABA/Cr、Glu/Cr的比值,比較三組受試者間的代謝差異.結果 與青年組比較,老年組和老年性聾組雙側聽皮層NAA/Cr降低,而Cho/Cr升高,差異具有統計學意義(P值均＜0.05)；老年組GABA/Cr、Glu/Cr比值與青年組相比,差異無統計學意義(P值均＞0.05)；老年性聾組GABA/Cr降低,Glu/Cr升高,與青年組相比差異具有統計學意義(P值均＜0.05).與老年組相比,老年性聾組雙側聽皮層NAA/Cr、GABA/Cr比值進一步降低,Cho/Cr、Glu/Cr比值進一步升高,差異具有統計學意義(P＜值均0.05).結論1H-MRS可以為人體活體聽皮層代謝物濃度改變提供有價值的信息.老年性聾患者聽皮層存在NAA、GABA代謝減少及Cho、Glu代謝升高的現象.
목적 이용경질자자공진파보(hydrogen magnetic resonance spectroscopy,1H-MRS)기술관찰노년성롱환자은피층적대사변화.방법 선취10명건강청년지원자(청년조)、10명은력정상노년인(노년조)급8례노년성롱환자(노년성롱조),분별행1 H-MRS검측기쌍측섭횡회N-을선천문동안산( N-acetylaspartic acid,NAA)、기산(creatine,Cr)、담감(choline,Cho)、γ-안기정산(γ-aminobutyric acid,GABA)급곡안산(glutamic acid,Glu)적봉하면적,계산기NAA/Cr、Cho/Cr、GABA/Cr、Glu/Cr적비치,비교삼조수시자간적대사차이.결과 여청년조비교,노년조화노년성롱조쌍측은피층NAA/Cr강저,이Cho/Cr승고,차이구유통계학의의(P치균＜0.05)；노년조GABA/Cr、Glu/Cr비치여청년조상비,차이무통계학의의(P치균＞0.05)；노년성롱조GABA/Cr강저,Glu/Cr승고,여청년조상비차이구유통계학의의(P치균＜0.05).여노년조상비,노년성롱조쌍측은피층NAA/Cr、GABA/Cr비치진일보강저,Cho/Cr、Glu/Cr비치진일보승고,차이구유통계학의의(P＜치균0.05).결론1H-MRS가이위인체활체은피층대사물농도개변제공유개치적신식.노년성롱환자은피층존재NAA、GABA대사감소급Cho、Glu대사승고적현상.
Objective To study the metabolic changes of auditory cortex in patients with presbycusis by using proton magnetic resonance spectroscopy(1H-MRS). Methods Ten normal hearing volunteers(youth group),10 normal hearing of elderly (aged group) and 8 patients with presbycusis (presbycusis group ) were checked with proton magnetic resonance spectroscopy. N-acetylaspartic acid ( NAA),creatine ( Cr),choline ( Cho),γ-aminobutyric acid (GABA),glutamic acid ( Glu ) compound were measured.The differences between the groups were semi-quantitatively analyzed.Results When compared with youth group,reduced NAA/Cr,increased Cho/Cr were found in the aged group and presbycusis group (P ＜ 0.05 ). GABA/Cr ratio and Glu/Cr ratio were significant difference between presbycusis group and youth group(P ＜ 0.05 ). There were no significant difference in the GABA/Cr and Glu/Cr ratios in the bilateral auditory cortex between the youth group and the aged group(P ＞ 0.05 ).When compared with aged group,the metabolic changes of auditory cortex in patients with presbycusis were remarkable ( P ＜ 0.05 ).Conclusions 1H-MRS is a noninvasive technique that can provide useful information concerning the metabolic changes of auditory cortex in human. In comparison to the aged group and the youth group,the changes of NAA,GABA,Cho and Glu is found in auditory cortex in patients with presbycusis.
