CAJ | 학술논문

目的探讨湖南土家族和苗族的谷胱甘肽S转移酶M1(GstM1)基因多态性分布情况。方法应用双重PCR方法检测152例土家族及106例苗族人群的(GstM1)基因型。结果土家族GstM1(－)基因型频率为43.4%(66/152)，苗族则为39.6%(42/106)，两组之间差异无显著性(P>0.05)，且同民族不同性别之间，不同民族同性别之间差异亦无显著性(均P>0.05)。结论湖南土家族和苗族的GstM1基因多态性分布与我国汉族及日本人相似，而与美国黑人及白人显著不同。
목적탐토호남토가족화묘족적곡광감태S전이매M1(GstM1)기인다태성분포정황。방법응용쌍중PCR방법검측152례토가족급106례묘족인군적(GstM1)기인형。결과토가족GstM1(－)기인형빈솔위43.4%(66/152)，묘족칙위39.6%(42/106)，량조지간차이무현저성(P>0.05)，차동민족불동성별지간，불동민족동성별지간차이역무현저성(균P>0.05)。결론호남토가족화묘족적GstM1기인다태성분포여아국한족급일본인상사，이여미국흑인급백인현저불동。
ObjectTo investigate the distribution ofglutathione-S-transferase M1 (Gst M1) gene polymorphism in Hunan Tujia and Miao nationalities. Methods The genotypes of Gst M1 in 152 Tujia and 106 Miao people were detected by dup licate PCR technique. Results The frequency of Gst M1 null genetype in Tujia nationality was 43.4%(66/152),whereas that in Miao nationality was 39.6% ( 42/106). No significant difference between the frequency of these two groups was observed (P>0.05).There were also no statistical differences between that of males and females within the same nationality as well as between that of the same sex belonged to different nationalities(P>0.05). Conclusion The Gst M1 gene polymorphism in Hunan Tujia and Miao nationalities is similar to tha t in Chinese Hans and Japanese, but significantly different from that in America n whites and blacks.