CAJ | 학술논문

调节性T细胞是当前免疫学研究的热点之一.人类天然调节性T细胞相当于小鼠CD4+CD25+T细胞,是正常发生于胸腺的特定细胞系,在体外对TCR刺激无反应,能抑制自身反应性T细胞.维持免疫的自身耐受.但在表面表型、分离方法和一些生物学特性方面存在差别.有证据提示,一些与自身免疫和变态反应有关的皮肤病存在调节性T细胞的功能障碍,应进一步研究.
조절성T세포시당전면역학연구적열점지일.인류천연조절성T세포상당우소서CD4+CD25+T세포,시정상발생우흉선적특정세포계,재체외대TCR자격무반응,능억제자신반응성T세포.유지면역적자신내수.단재표면표형、분리방법화일사생물학특성방면존재차별.유증거제시,일사여자신면역화변태반응유관적피부병존재조절성T세포적공능장애,응진일보연구.
Regulatory T cells are now a focus of immunology research. Human naturally occurring regulatory T cells derive from thymus. They have no response to T cell receptors in vitro, could suppress autoreactive T cells and maintain autoimmune tolerance. They are very similar to mouse CD4+CD25+ T cells in many aspects except in surface phenotype, isolation methods, and some biological characteristics. There is accumulating evidence that regulatory T cells have functional deficiencies in some cutaneous disorders related to autoimmunity and allergy. This is a domain that deserves further study.