CAJ | 학술논문

目的探讨胃癌组织中转移抑制基因23一H1(nm23-H1)蛋白表达与胃癌浸润转移的关系.方法采用免疫组化SP法,检测50例胃癌组织中nm23-H1蛋白.结果 nm23一H1蛋白的表达与胃癌浸润深度和胃癌组织的分化程度无关,与淋巴结转移及TNM分期有关.结论 nm23-H1能够抑制胃癌浸润转移.nm23-H1蛋白低表达对判断病变进展及转移和复发有重要参考价值.
목적 탐토위암조직중전이억제기인23일H1(nm23-H1)단백표체여위암침윤전이적관계.방법 채용면역조화SP법,검측50례위암조직중nm23-H1단백.결과 nm23일H1단백적표체여위암침윤심도화위암조직적분화정도무관,여림파결전이급TNM분기유관.결론 nm23-H1능구억제위암침윤전이.nm23-H1단백저표체대판단병변진전급전이화복발유중요삼고개치.
Objective To study the relationship of expression of metastasis suppressor gene nin23-H1 protein in gastric carcinoma tissue and tumor infiltration and metastasis.Methods The expression of metastasis suppressor gene nm23-H1 protein in 50 gastric carcinoma tissues was detected by SP immunohistocbemistry tech-nology.Results Correlations were presented among expression of nm23-H1 protein, infiltrate grade of gastric carcinoma, lymph node metastasis and TNM stage.Conclusions Expression of nm23-H1 may suppress infiltra-tion and metastasis of gastric carcinoma, Low expression of nm23-H1 protein may be of great reference value in judgement of tumor progression, metastasis and reeidivation.