国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2011年
1期
48-51
,共4页
中成药软膏%湿疹%随机对照试验%Meta分析%发表性偏倚
中成藥軟膏%濕疹%隨機對照試驗%Meta分析%髮錶性偏倚
중성약연고%습진%수궤대조시험%Meta분석%발표성편의
Chinese patent medicinal ointment%Eczema%Randomized control trial%Meta analysis%Publication bias
目的 系统分析中成药软膏治疗湿疹的有效性、安全性,以期做出客观、可信的评价,指导临床研究.方法 计算机检索VIP数据库(1989～2008)、CHKD(1994～2008),纳入以湿疹患者为研究对象、比较中成药软膏与西药洗剂疗效的随机对照试验,评价纳入研究的质量,采用Jadad量表记分法,并用RevMan4.2.7进行Meta分析.结果 共纳入11个随机对照试验共计1461例患者.Meta分析显示:①异质性检验:固定效应模型分析发现Q=16.57,P=0.08>0.05,表明研究间的效应量是同质的.②合并效应量OR合并=0.41,95%的置信区间为[0.29,0.58].③x2=5.04(P<0.01),总体OR合并有统计学意义,说明中成药软膏临床有效率明显高于西药对照组.结论 中成药软膏治疗湿疹是一种有效的方法,且未发现较重的副作用.但由于存在发表偏倚和普遍低质量的随机对照试验,而致结论的可信度降低.
目的 繫統分析中成藥軟膏治療濕疹的有效性、安全性,以期做齣客觀、可信的評價,指導臨床研究.方法 計算機檢索VIP數據庫(1989～2008)、CHKD(1994～2008),納入以濕疹患者為研究對象、比較中成藥軟膏與西藥洗劑療效的隨機對照試驗,評價納入研究的質量,採用Jadad量錶記分法,併用RevMan4.2.7進行Meta分析.結果 共納入11箇隨機對照試驗共計1461例患者.Meta分析顯示:①異質性檢驗:固定效應模型分析髮現Q=16.57,P=0.08>0.05,錶明研究間的效應量是同質的.②閤併效應量OR閤併=0.41,95%的置信區間為[0.29,0.58].③x2=5.04(P<0.01),總體OR閤併有統計學意義,說明中成藥軟膏臨床有效率明顯高于西藥對照組.結論 中成藥軟膏治療濕疹是一種有效的方法,且未髮現較重的副作用.但由于存在髮錶偏倚和普遍低質量的隨機對照試驗,而緻結論的可信度降低.
목적 계통분석중성약연고치료습진적유효성、안전성,이기주출객관、가신적평개,지도림상연구.방법 계산궤검색VIP수거고(1989～2008)、CHKD(1994～2008),납입이습진환자위연구대상、비교중성약연고여서약세제료효적수궤대조시험,평개납입연구적질량,채용Jadad량표기분법,병용RevMan4.2.7진행Meta분석.결과 공납입11개수궤대조시험공계1461례환자.Meta분석현시:①이질성검험:고정효응모형분석발현Q=16.57,P=0.08>0.05,표명연구간적효응량시동질적.②합병효응량OR합병=0.41,95%적치신구간위[0.29,0.58].③x2=5.04(P<0.01),총체OR합병유통계학의의,설명중성약연고림상유효솔명현고우서약대조조.결론 중성약연고치료습진시일충유효적방법,차미발현교중적부작용.단유우존재발표편의화보편저질량적수궤대조시험,이치결론적가신도강저.
Objective To systematically analyze the effectiveness and security of Chinese medicinal ointment treating eczema for the purpose of making an objective and creditable evaluation and guiding clinical usage. Methods Data in the VIP database (1989-2008) and CHKD (1994-2008) were researched and literatures on the treatment of eczema were included. Randomized control trails (RCTs) of therapeutic effects were compared between Chinese medicinal ointment and western medical treatment. Jadad Scale was adopted and RevMan4.2.7 was used to conduct Мeta analysis. Results 11 RCTs were adopted, including 1415 cases.① Heterogeneity Test: It was found through analysis with fixed effect model that Q= 16.57, and P=0.08>0.05,which indicated that the effective between studies are homogenous. ② Total effect size' ORunited was 0.17,with the 95% confidence interval [0.29,0.58]. ③ x2=5.04 (P<0.01), P<0.05, the total ORunited had statistic significance, which indicated that the treatment of eczema with the Chinese Medicinal Ointment was obviously better than that of western medicinal Ointment. Conclusion It is a effective method to treat eczema with Chinese Medicinal Ointment, and there is no serious ADR. However, because of publication bias and RCTs of universal lower quality, the credibility of the conclusion was reduced.
