中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2010年
5期
501-503
,共3页
郭怀斌%张万星%王兰辉%谭文科
郭懷斌%張萬星%王蘭輝%譚文科
곽부빈%장만성%왕란휘%담문과
幽门螺杆菌%细胞毒素相关基因抗原%胆汁%胃炎
幽門螺桿菌%細胞毒素相關基因抗原%膽汁%胃炎
유문라간균%세포독소상관기인항원%담즙%위염
Helicobacter,pylori%Cytotoxin associated gene antigen%Bile%Gastritis
目的 探讨胆囊内胆汁幽门螺杆菌(Hp)DNA检出与胃Hp感染的关系及可能的机制.方法 采用13C-呼气实验检测60例胆囊良性疾病患者胃幽门螺杆茵,并根据结果分为胃Hp感染阳性组和胃Hp感染阴性组,用PCR方法 检测2组患者的胆汁及结石Hp细胞毒素相关基因抗原(cagA),另选健康人30名作为对照,B超测定3组胆囊排空率.结果 60例胆囊良性疾病患者胃Hp感染率为50.0%(30/60),胃Hp感染阳性组胆汁标本中cagA阳性7例(23.3%,7/30),结石标本中cagA阳性1例(3.3%,1/30),胃Hp感染阴性组胆汁和结石标本均为阴性,2组胆汁cagA检出率差异有统计学意义(x2=5.822,P＜0.05),胃Hp感染阳性组胆囊收缩率[(56.8±17.1)%]明显低于胃Hp感染阴性组[(69.4±13.1)%]和对照组[(63.3±17.1)%],差异有统计学意义(F=5.633,P＜0.05).结论 胆囊内胆汁中存在Hp DNA,且与胃Hp感染明显有关,胆囊排空功能障碍参与了这一过程.
目的 探討膽囊內膽汁幽門螺桿菌(Hp)DNA檢齣與胃Hp感染的關繫及可能的機製.方法 採用13C-呼氣實驗檢測60例膽囊良性疾病患者胃幽門螺桿茵,併根據結果分為胃Hp感染暘性組和胃Hp感染陰性組,用PCR方法 檢測2組患者的膽汁及結石Hp細胞毒素相關基因抗原(cagA),另選健康人30名作為對照,B超測定3組膽囊排空率.結果 60例膽囊良性疾病患者胃Hp感染率為50.0%(30/60),胃Hp感染暘性組膽汁標本中cagA暘性7例(23.3%,7/30),結石標本中cagA暘性1例(3.3%,1/30),胃Hp感染陰性組膽汁和結石標本均為陰性,2組膽汁cagA檢齣率差異有統計學意義(x2=5.822,P＜0.05),胃Hp感染暘性組膽囊收縮率[(56.8±17.1)%]明顯低于胃Hp感染陰性組[(69.4±13.1)%]和對照組[(63.3±17.1)%],差異有統計學意義(F=5.633,P＜0.05).結論 膽囊內膽汁中存在Hp DNA,且與胃Hp感染明顯有關,膽囊排空功能障礙參與瞭這一過程.
목적 탐토담낭내담즙유문라간균(Hp)DNA검출여위Hp감염적관계급가능적궤제.방법 채용13C-호기실험검측60례담낭량성질병환자위유문라간인,병근거결과분위위Hp감염양성조화위Hp감염음성조,용PCR방법 검측2조환자적담즙급결석Hp세포독소상관기인항원(cagA),령선건강인30명작위대조,B초측정3조담낭배공솔.결과 60례담낭량성질병환자위Hp감염솔위50.0%(30/60),위Hp감염양성조담즙표본중cagA양성7례(23.3%,7/30),결석표본중cagA양성1례(3.3%,1/30),위Hp감염음성조담즙화결석표본균위음성,2조담즙cagA검출솔차이유통계학의의(x2=5.822,P＜0.05),위Hp감염양성조담낭수축솔[(56.8±17.1)%]명현저우위Hp감염음성조[(69.4±13.1)%]화대조조[(63.3±17.1)%],차이유통계학의의(F=5.633,P＜0.05).결론 담낭내담즙중존재Hp DNA,차여위Hp감염명현유관,담낭배공공능장애삼여료저일과정.
Objective To study the relationship between Helicobacter pylori (Hp) DNA positive detection in bile of gallbladder and intragastric Hp's colony and its plausible mechanism.Methods Sixty patients of gallbladder innocence diseases were recruited in the case group and 30 health populations were recruited in the control group.13CPDB was used to detect the infection of Hp.The cytotoxin associated gene antigen (cagA) in gall and gall-stone were detected through PCR.The empty function was tested through B ultrasound.Results The infection rate of Hp in all cases is 50.0% (30/60) and 7 of 30 bile (23.3%) ,1 of 30 gallstones (3.3%) were positive for Hp cag-A by PCR analysis in positive Hp infection group,with none of the 30 bile were positive in negative group( x2 = 5.822 ,P ＜ 0.05 ).The contraction rate of gallbladder of Hp positive group ( 56.8 ± 17.1 ) %was lower than negetive group' s ( 69.4 ± 13.1 ) % and the control group' s (63.3 ± 17.1 ) % ( F = 5.633,P ＜0.05).Conclusions Hp DNA is present in bile of gallbladder,and is related with Hp infection in stomach.Impairment of the gallbladder empty function may be related with Hp infection.
