CAJ | 학술논문

目的探讨参加美沙酮维持治疗的阿片类药物依赖者的抑郁状况及其与患者生命质量的关系.方法使用贝克抑郁量表21项版(BDI-21)、药物成瘾者生命质量测定(QOL-DA)对120例美沙酮维持治疗门诊的阿片类药物依赖者进行横断面调查.结果 ≥41岁组患者生命质量的躯体功能维度分[(28.79±8.53)分]显著低于31～40岁组[(33.52±6.73)分],差异具有显著性(P=0.003).55%参加美沙酮维持治疗的阿片类药物依赖者BDI-21量表评分为中、重度抑郁.按BDI-21评分将患者分组为无抑郁、轻度抑郁、中度抑郁和重度抑郁组,其QOL-DA量表评分依次降低,差异有统计学意义(P<0.01).患者BDI-21量表总分与QOL-DA量表评分呈显著负相关,相关分析具有统计学意义(均P<0.01).结论参加美沙酮维持治疗的阿片类药物依赖者常合并抑郁并影响患者生命质量,需要对患者加强抑郁干预或治疗.
목적 탐토삼가미사동유지치료적아편류약물의뢰자적억욱상황급기여환자생명질량적관계.방법 사용패극억욱량표21항판(BDI-21)、약물성은자생명질량측정(QOL-DA)대120례미사동유지치료문진적아편류약물의뢰자진행횡단면조사.결과 ≥41세조환자생명질량적구체공능유도분[(28.79±8.53)분]현저저우31～40세조[(33.52±6.73)분],차이구유현저성(P=0.003).55%삼가미사동유지치료적아편류약물의뢰자BDI-21량표평분위중、중도억욱.안BDI-21평분장환자분조위무억욱、경도억욱、중도억욱화중도억욱조,기QOL-DA량표평분의차강저,차이유통계학의의(P<0.01).환자BDI-21량표총분여QOL-DA량표평분정현저부상관,상관분석구유통계학의의(균P<0.01).결론 삼가미사동유지치료적아편류약물의뢰자상합병억욱병영향환자생명질량,수요대환자가강억욱간예혹치료.
Objective To explore the depression status and its con-elation with quality of life(QOL) in patients receiving methadone maintenance treatment (MMT). Methods 120 patients treated with MMT were assessed with Quality of Life Scale for Drug Addicts (QOL-DA) and Beck Depression Inventory (BDI-21). Results More than 41 years old group's QOL-DA physical function domain(28.79 ±8.53) was significantly lower than 31～40 years old group (33.52 ± 6. 73) (P= 0.003). According to BDI-21 score ,55% patients receiving MMT were classified as moderate or severe depression. QOL-DA scores decreased in order of the depression severity classified as no depression group,mild depression group,moderate depression group and severe depression group according to the BDI-21 score,and the difference between the groups were significant statistically (P<0.01). There was significantly negative correlation between BDI-21 score and QOL-DA score (P<0.01). Conclusion Depression is very common in opioid dependent patients receiving MMT and decreases their quality of life,so it is important to enhance depression intervention or treatment in MMT clinics.