中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2012年
6期
722-723
,共2页
二异丙酚%清醒镇静%吞咽%药物释放系统
二異丙酚%清醒鎮靜%吞嚥%藥物釋放繫統
이이병분%청성진정%탄인%약물석방계통
Propofol%Conscious sedation%Deglutition%Drug delivery systems
目的 确定TCI异丙酚抑制吞咽反射的镇静深度.方法 35名健康志愿者,年龄20～60岁,BMI＜30 kg/m2,ASA分级Ⅰ或Ⅱ级.TCI异丙酚镇静,第1名志愿者初始血浆靶浓度为2.4μg/ml,每5 min升高或降低靶浓度0.2μg/ml,使BIS值达到设定值,下一名志愿者血浆靶浓度根据BIS值相应地升高或降低0.3 μg/ml.采用改良序贯法进行试验,第1名志愿者BIS值为65,根据是否发生吞咽反射确定下一名志愿者BIS值,相邻BIS值的比值为1.1.采用序贯法计算半数志愿者抑制吞咽反射的BIS值(BIS50)及其95％可信区间(CI).结果 TCI异丙酚抑制咽反射的BIS50及其95％CI为64.4(59.3 - 69.8).结论 TCI异丙酚抑制吞咽反射的BIS50及其95％CI为64.4(59.3～69.8).
目的 確定TCI異丙酚抑製吞嚥反射的鎮靜深度.方法 35名健康誌願者,年齡20～60歲,BMI＜30 kg/m2,ASA分級Ⅰ或Ⅱ級.TCI異丙酚鎮靜,第1名誌願者初始血漿靶濃度為2.4μg/ml,每5 min升高或降低靶濃度0.2μg/ml,使BIS值達到設定值,下一名誌願者血漿靶濃度根據BIS值相應地升高或降低0.3 μg/ml.採用改良序貫法進行試驗,第1名誌願者BIS值為65,根據是否髮生吞嚥反射確定下一名誌願者BIS值,相鄰BIS值的比值為1.1.採用序貫法計算半數誌願者抑製吞嚥反射的BIS值(BIS50)及其95％可信區間(CI).結果 TCI異丙酚抑製嚥反射的BIS50及其95％CI為64.4(59.3 - 69.8).結論 TCI異丙酚抑製吞嚥反射的BIS50及其95％CI為64.4(59.3～69.8).
목적 학정TCI이병분억제탄인반사적진정심도.방법 35명건강지원자,년령20～60세,BMI＜30 kg/m2,ASA분급Ⅰ혹Ⅱ급.TCI이병분진정,제1명지원자초시혈장파농도위2.4μg/ml,매5 min승고혹강저파농도0.2μg/ml,사BIS치체도설정치,하일명지원자혈장파농도근거BIS치상응지승고혹강저0.3 μg/ml.채용개량서관법진행시험,제1명지원자BIS치위65,근거시부발생탄인반사학정하일명지원자BIS치,상린BIS치적비치위1.1.채용서관법계산반수지원자억제탄인반사적BIS치(BIS50)급기95％가신구간(CI).결과 TCI이병분억제인반사적BIS50급기95％CI위64.4(59.3 - 69.8).결론 TCI이병분억제탄인반사적BIS50급기95％CI위64.4(59.3～69.8).
Objective To determine the depth of sedation induced by target-controlled infusion (TCI) of propofol required to inhibit the swallowing reflex.Methods Thirty-five ASA Ⅰ or Ⅱ healthy volunteers,aged 20-60 yr,with body mass index ＜ 30 kg/m2,were enrolled in the study.Sedation was performed with TCI of propofol.The initial target plasma concentration (Cp) of propofol was set at 2.4 μg/ml and the Cp increased or decreased by 0.2 μg/ml every 5 min until the BIS value reached the predetermined level.The initial Cp of propofol was increased or decreased by 0.3 μg/ml in the next subject according to the BIS value in the previous one.The up-and-down sequential experiment was pedormed.The BIS value was set at 65 in the first subject and the ratio of the BIS value between the two consecutive subjects was 1.1.The BIS value was increased or decreased depending on the occurrence of the swallowing reflex in the previous subject.The half-effective BIS value (BIS50) and 95％confidence interval (CI) of propofol inhibiting the swallowing reflex were calculated by up-and-down sequential method.Results The BIS50 of propofol required to inhibit the swallowing reflex was 64.4 (95％ CI 59.3-69.8).Conclusion The BIS50 and 95％ CI of propofol administered by TCI and required to inhibit the swallowing reflex is 64,4 (59.3-69.8).
