CAJ | 학술논문

背景:间充质干细胞能自我更新、高度增殖,具有多向分化潜能、低免疫原性及免疫调节特性.在体内和体外均能调节同种异体免疫反应,在实体器官移植中发挥着重要作用,有望成为诱导移植耐受的新途径.目的:综述间充质干细胞在实体器官移植中的应用及其免疫调节机制的最新进展.方法:应用计算机检索Pubmed 1994-01/2009-10期间相关文章,运用MeSH主题词检索,检索词为"Mesenchymal Stem Cells, Mesenchymal Stem cell Transplantation,Organ Transplantation,Transplantation Immunology, Immunologic Graft Enhancement,Graft vs Host Disease",并限定文章语言种类为"English".同时计算机检索万方数据库1994-01/2009-10期间相关文章,检索词为"间充质干细胞、器官移植、移植免疫".纳入标准:文章所述内容应与间充质干细胞免疫学特性、器官移植中的应用及移植免疫进展研究相关.排除标准:重复研究或Meta分析类文章.结果与结论:共收集到200篇相关文献,86篇文献符合纳入标准.间充质干细胞具有低免疫原性及调节免疫调节特性,在诱导移植耐受和器官移植后组织修复中有着不可或缺的优势,其诱导免疫耐受的机制可能与町溶性因子、调节性T细胞、耐受性树突细胞、骨髓嵌合状态、抗炎和组织修复功能有关,并受间充质干细胞输入方式、剂量与时间的影响.
배경:간충질간세포능자아경신、고도증식,구유다향분화잠능、저면역원성급면역조절특성.재체내화체외균능조절동충이체면역반응,재실체기관이식중발휘착중요작용,유망성위유도이식내수적신도경.목적:종술간충질간세포재실체기관이식중적응용급기면역조절궤제적최신진전.방법:응용계산궤검색Pubmed 1994-01/2009-10기간상관문장,운용MeSH주제사검색,검색사위"Mesenchymal Stem Cells, Mesenchymal Stem cell Transplantation,Organ Transplantation,Transplantation Immunology, Immunologic Graft Enhancement,Graft vs Host Disease",병한정문장어언충류위"English".동시계산궤검색만방수거고1994-01/2009-10기간상관문장,검색사위"간충질간세포、기관이식、이식면역".납입표준:문장소술내용응여간충질간세포면역학특성、기관이식중적응용급이식면역진전연구상관.배제표준:중복연구혹Meta분석류문장.결과여결론:공수집도200편상관문헌,86편문헌부합납입표준.간충질간세포구유저면역원성급조절면역조절특성,재유도이식내수화기관이식후조직수복중유착불가혹결적우세,기유도면역내수적궤제가능여정용성인자、조절성T세포、내수성수돌세포、골수감합상태、항염화조직수복공능유관,병수간충질간세포수입방식、제량여시간적영향.
BACKGROUND:Mesenchymal stem cells are capable of self-renew,a high degree of proliferation,with multi-differentiation potential,low immunogenicity and immunomodulatory properties.Both in vivo and in vitro it is able to regulate allogeneic immune response,to induce immune tolerance.In the solid organ transplantation it is playing an increasingly important role.OBJECTIVE:To summarize the research progress on the immunomodulatory mechanism and application of mesenchymal stem cells in solid organ transplantation.METHODS:An online search of Pubmed was undertaken by using the key words of "Mesenchymal Stem Cells,Mesenchymal Stem Cell Transplantation,Organ Transplantation,Transplantation Immunology,Immunologic Graft Enhancement,Graft vs.Host Disease" in Mesh to identify the relevant articles published in English from January 1994 to October 2009.At the same time,Wanfang database was screened to identify the relevant articles published between January 1994 and October 2009 with the key words of "Mesenchymal Stem Cells,Organ Transplantation,Transplantation Immunology" in Chinese.Inclusive criterion:The articles related to the immunomodulatory properties,transplantation immunology and application of mesenchymal stem calls in the solid organ transplantation were included.Exclusive criterion:The articles with repetitive research or Meta analysis were excluded.RESULTS AND CONCLUSION:Totally 200 relevant articles were selected and 86 of them met the inclusive criterion.Mesenchymal stem cells exhibit low immunogenicity and immunomodulatory properties,have an indispensable advantage about inducing graft tolerance and repairing tissue in solid organ transplantation.The mechanism of inducting immune tolerance may be related to soluble factors,regulatory T cells,tolerant dendritic cells,bone marrow chimerism,anti-inflammatory and tissue repair,dose and time of injecting MSCs.