中华烧伤杂志
中華燒傷雜誌
중화소상잡지
16
2012年
1期
51-53
,共3页
糖尿病%糖尿病神经病变%皮肤%伤口愈合%微血管病变
糖尿病%糖尿病神經病變%皮膚%傷口愈閤%微血管病變
당뇨병%당뇨병신경병변%피부%상구유합%미혈관병변
Diabetes mellitus%Diabetic neuropathies%Skin%Wound healing%Microangiopathy
The diabetic ulceration is not uncommon,and becomes refractory,as the skin in a diabetic patient is relatively thin as well as hypoesthetic and less sensitive to temperature.As there are already preexisting histological and cellular derangement in the skin,healing of the skin injury is difficult,thus resulting in an intractable ulceration.When diabetes is not controlled,the skin contents of sugar and advanced glycation end product accumulate,invoking cellular deformation and accumulation of matrix metalloproteinases(MMP),resulting in an imbalance between MMP and its inhibitors, malfunction of growth factors,and inflammatory reaction.These processes lead to obvious skin thinning,denaturation of connective tissues,thickening of vascular basal membrane,and neuropathy,etc.These pathological alterations could be recognized as " covert disorder" of skin in diabetic patients and may be underlying disorders in producing indolent diabetic ulcers.
