中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
12期
1585-1586
,共2页
黄斌%张盛斌%黄林欢%朱红军%刘朝晖%赵子文%谢灿茂
黃斌%張盛斌%黃林歡%硃紅軍%劉朝暉%趙子文%謝燦茂
황빈%장성빈%황림환%주홍군%류조휘%조자문%사찬무
大肠埃希菌%肺炎克雷伯菌%超广谱β-内酰胺酶%耐药性
大腸埃希菌%肺炎剋雷伯菌%超廣譜β-內酰胺酶%耐藥性
대장애희균%폐염극뢰백균%초엄보β-내선알매%내약성
Escherichia coli%Klebsiella pneumonia%Extended-spectrum beta-lactamases%Antibiotic resistance
目的 研究汕头地区革兰阴性杆菌产超广谱β-内酰胺酶(ESBLs)情况及其耐药特性,为临床合理使用抗生素提供依据.方法 收集汕头地区革兰阴性杆菌共1 445株(大肠埃希菌895株和肺炎克雷伯菌550株),采用Vitek-2全自动细菌鉴定和药敏分析仪进行ESBL检测和药敏实验.结果 69.4%大肠埃希菌和33.6%肺炎克雷伯菌产ESBLs.产ESBLs菌株对青霉素类、头孢菌素类和单环类抗生素的耐药率极高;产ESBLs菌株存在多重耐药性,而且对多种抗生素的耐药率明显比不产ESBLs菌株高;产ESBLs菌株和不产ESBLs菌株对亚胺培南均未出现耐药.结论 汕头地区革兰阴性杆菌中ESBLs菌株检出率高;产ESBLs菌株耐药性比不产ESBLs菌株高,且耐药表型多样性;亚胺培南是临床治疗产ESBLs菌株感染的首选药物.
目的 研究汕頭地區革蘭陰性桿菌產超廣譜β-內酰胺酶(ESBLs)情況及其耐藥特性,為臨床閤理使用抗生素提供依據.方法 收集汕頭地區革蘭陰性桿菌共1 445株(大腸埃希菌895株和肺炎剋雷伯菌550株),採用Vitek-2全自動細菌鑒定和藥敏分析儀進行ESBL檢測和藥敏實驗.結果 69.4%大腸埃希菌和33.6%肺炎剋雷伯菌產ESBLs.產ESBLs菌株對青黴素類、頭孢菌素類和單環類抗生素的耐藥率極高;產ESBLs菌株存在多重耐藥性,而且對多種抗生素的耐藥率明顯比不產ESBLs菌株高;產ESBLs菌株和不產ESBLs菌株對亞胺培南均未齣現耐藥.結論 汕頭地區革蘭陰性桿菌中ESBLs菌株檢齣率高;產ESBLs菌株耐藥性比不產ESBLs菌株高,且耐藥錶型多樣性;亞胺培南是臨床治療產ESBLs菌株感染的首選藥物.
목적 연구산두지구혁란음성간균산초엄보β-내선알매(ESBLs)정황급기내약특성,위림상합리사용항생소제공의거.방법 수집산두지구혁란음성간균공1 445주(대장애희균895주화폐염극뢰백균550주),채용Vitek-2전자동세균감정화약민분석의진행ESBL검측화약민실험.결과 69.4%대장애희균화33.6%폐염극뢰백균산ESBLs.산ESBLs균주대청매소류、두포균소류화단배류항생소적내약솔겁고;산ESBLs균주존재다중내약성,이차대다충항생소적내약솔명현비불산ESBLs균주고;산ESBLs균주화불산ESBLs균주대아알배남균미출현내약.결론 산두지구혁란음성간균중ESBLs균주검출솔고;산ESBLs균주내약성비불산ESBLs균주고,차내약표형다양성;아알배남시림상치료산ESBLs균주감염적수선약물.
Objective To investigate the extended-spectrum beta-lactamases ( ESBLs) producing clinical isolates of gram negative bacilli and their antibiotic resistance in Shantou and to provide suggestions on empirical treatment against the bacteria.Methods A total of 1 445 strains of gram negative bacilli (895 strains of Escherichia coli and 550 strains of Klebsiella pneumonia) were collected and examined for the production of ESBLs and antibacterial susceptibility test by Vitek-2.Results There were 69.4% of escherichia coli and 33.6% of klebsiella pneumonia producing ESBLs.The resistance rate of the ESBLs-producing strains to penicillins,cephalosporins and monocyclic beta-lactam antibiotics were very high.The ESBLs-producing strains were multidrug resistant and the resistance rates were higher than that of the non-ESBLs-producing strains.Both ESBLs-producing and non-ESBLs-producing strains were susceptible to Imipenem.Conclusion The incidence of ESBLs-producing strains was high in gram negative bacilli in Shantou.The resistance rates of the ESBLs-producing strains were higher than that of the non-ESBLs-producing strains and they expressed multiple drug resistance phenotypes.Imipenem was the best drug in the treatment of infections caused by ESBLs-producing strains.
